There are several known routes for the metabolic detoxication of α,β-unsaturated aldehydes
and ketones, including conjugation to glutathione and reduction and oxidation of the …

Neonicotinoid insecticide metabolism involves considerable substrate specificity and
regioselectivity of the relevant CYP450, aldehyde oxidase, and phase II enzymes. Human CYP450 …

Imidacloprid (IMI), the prototypical neonicotinoid insecticide, is used worldwide for crop
protection and flea control on pets. It is both oxidatively metabolized by cytochrome P450 …

Four neonicotinoid nitroguanidine insecticides (imidacloprid, thiamethoxam, clothianidin, and
dinotefuran) acting as nicotinic agonists account for 10−15% of worldwide insecticide sales…

Glycogen synthase 1 (GYS1), the rate-limiting enzyme in muscle glycogen synthesis, plays
a central role in energy homeostasis and has been proposed as a therapeutic target in …

To identify aldehyde oxidase (AO) substrates, an assay procedure was developed that
leverages the capabilities of high-resolution mass spectrometry to simultaneously monitor parent …

The nitroguanidine or nitromethylene moiety of the newest major class of insecticides, the
neonicotinoids, is important for potency at insect nicotinic receptors and selectivity relative to …

NADPH-dependent alkenal/one oxidoreductase (AOR) from the rat is a phase 2/antioxidative
enzyme that is known to catalyze the reduction of the carbon-carbon double bond of α,β-…

Illudins S and M are extremely cytotoxic products of the fungus Omphalotus illudens. They
were evaluated as possible anticancer chemotherapeutic agents but displayed unfavorable …

Chronic hepatitis B (CHB) virus infection afflicts hundreds of millions of people and causes
nearly one million deaths annually. The high levels of circulating viral surface antigen (HBsAg…