The tissue distribution kinetics of iv Cyclosporine A (CyA) was investigated extensively in
rats. The concentration-to-time data of 11 organs were analyzed separately using local …

The immunosuppressant, SDZ IMM 125 (IMM), is a derivative of cyclosporin A (CyA). The
disposition kinetics of IMM in plasma, blood cells, and various tissues of the rat was …

A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the
determination of valsartan in human plasma was developed and validated. A 0.5ml aliquot …

Cyclosporin A (CyA) tissue distribution kinetics was extensively studied after single 1.2-, 6-,
and 30-mg/kg CyA doses (via 2-min iv infusion) to rats. Drug concentrations in blood and …

Since the pioneering work of Haggard and Teorell in the first half of the 20th century, and of
Bischoff and Dedrick in the late 1960s, physiologically based pharmacokinetic (PBPK) …

PSC 833 has been used to overcome the phenomenon of multidrug resistance by inhibiting
the P-glycoprotein (P-gp)-mediated efflux of antitumor drugs from tumor cells. Because P-gp …

Everolimus is a novel macrolide immunosuppressant developed for the prophylaxis of
allogeneic renal or cardiac transplant rejection. Treatments with immunosuppressants are often …

The disposition kinetics of Cyclosporine A (CyA) in rat, based on measurement in arterial
blood, appeared dose-linear over a wide iv dose range (1.2–30mg/kg). Physiologically based …

A convenient and sensitive high-performance liquid chromatographic assay for the simultaneous
quantitation of lidocaine and its four metabolites has been developed. The samples …

Long‐acting repeatable formulations (LAR) based on polymeric microspheres were manufactured
to deliver octreotide, an octapeptide analogue used in acromegaly. We developed a …