Physiologically based pharmacokinetics of cyclosporine A: extension to tissue distribution kinetics in rats and scale-up to human
R Kawai, D Mathew, C Tanaka, M Rowland - Journal of Pharmacology and …, 1998 - ASPET
The tissue distribution kinetics of iv Cyclosporine A (CyA) was investigated extensively in
rats. The concentration-to-time data of 11 organs were analyzed separately using local …
rats. The concentration-to-time data of 11 organs were analyzed separately using local …
Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125
R Kawai, M Lemaire, JL Steimer, A Bruelisauer… - … of pharmacokinetics and …, 1994 - Springer
The immunosuppressant, SDZ IMM 125 (IMM), is a derivative of cyclosporin A (CyA). The
disposition kinetics of IMM in plasma, blood cells, and various tissues of the rat was …
disposition kinetics of IMM in plasma, blood cells, and various tissues of the rat was …
Development and validation of a method for quantitative determination of valsartan in human plasma by liquid chromatography-tandem mass spectrometry
…, H Hara, M Niina, M Tanaka, R Kawai… - … of pharmaceutical and …, 2007 - Elsevier
A sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the
determination of valsartan in human plasma was developed and validated. A 0.5ml aliquot …
determination of valsartan in human plasma was developed and validated. A 0.5ml aliquot …
Dose-dependent pharmacokinetics of cyclosporin A in rats: events in tissues
C Tanaka, R Kawai, M Rowland - Drug metabolism and disposition, 2000 - ASPET
Cyclosporin A (CyA) tissue distribution kinetics was extensively studied after single 1.2-, 6-,
and 30-mg/kg CyA doses (via 2-min iv infusion) to rats. Drug concentrations in blood and …
and 30-mg/kg CyA doses (via 2-min iv infusion) to rats. Drug concentrations in blood and …
Physiologically based pharmacokinetic modeling as a tool for drug development
SB Charnick, R Kawai, JR Nedelman… - … of pharmacokinetics and …, 1995 - Springer
Since the pioneering work of Haggard and Teorell in the first half of the 20th century, and of
Bischoff and Dedrick in the late 1960s, physiologically based pharmacokinetic (PBPK) …
Bischoff and Dedrick in the late 1960s, physiologically based pharmacokinetic (PBPK) …
Effect of PSC 833, a P-glycoprotein modulator, on the disposition of vincristine and digoxin in rats
SH Song, H Suzuki, R Kawai, Y Sugiyama - Drug Metabolism and …, 1999 - ASPET
PSC 833 has been used to overcome the phenomenon of multidrug resistance by inhibiting
the P-glycoprotein (P-gp)-mediated efflux of antitumor drugs from tumor cells. Because P-gp …
the P-glycoprotein (P-gp)-mediated efflux of antitumor drugs from tumor cells. Because P-gp …
Physiologically based pharmacokinetic (PBPK) modeling of everolimus (RAD001) in rats involving non-linear tissue uptake
R Laplanche, GML Meno-Tetang, R Kawai - Journal of pharmacokinetics …, 2007 - Springer
Everolimus is a novel macrolide immunosuppressant developed for the prophylaxis of
allogeneic renal or cardiac transplant rejection. Treatments with immunosuppressants are often …
allogeneic renal or cardiac transplant rejection. Treatments with immunosuppressants are often …
Physiologically based pharmacokinetics of cyclosporine a: reevaluation of dose–nonlinear kinetics in rats
C Tanaka, R Kawai, M Rowland - Journal of pharmacokinetics and …, 1999 - Springer
The disposition kinetics of Cyclosporine A (CyA) in rat, based on measurement in arterial
blood, appeared dose-linear over a wide iv dose range (1.2–30mg/kg). Physiologically based …
blood, appeared dose-linear over a wide iv dose range (1.2–30mg/kg). Physiologically based …
Simultaneous quantitation of lidocaine and its four metabolites by high-performance liquid chromatography: application to studies on in vitro and in vivo metabolism of …
R Kawai, S Fujita, T Suzuki - Journal of pharmaceutical sciences, 1985 - Elsevier
A convenient and sensitive high-performance liquid chromatographic assay for the simultaneous
quantitation of lidocaine and its four metabolites has been developed. The samples …
quantitation of lidocaine and its four metabolites has been developed. The samples …
Modeling the kinetics of release of octreotide from long‐acting formulations injected intramuscularly in rabbits
Long‐acting repeatable formulations (LAR) based on polymeric microspheres were manufactured
to deliver octreotide, an octapeptide analogue used in acromegaly. We developed a …
to deliver octreotide, an octapeptide analogue used in acromegaly. We developed a …