SOX10 regulates melanoma immunogenicity through an IRF4–IRF1 Axis

S Yokoyama, A Takahashi, R Kikuchi, S Nishibu, JA Lo… - Cancer research, 2021 - AACR
This study identifies a novel SOX10/IRF4 pathway that regulates noncanonical induction of
IRF1 independent of the JAK–STAT pathway and can be targeted to improve the efficacy of …

Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1α/β and DNA methylation

R Kikuchi, H Kusuhara, N Hattori, K Shiota, I Kim… - Molecular …, 2006 - ASPET
Human organic anion transporter 3 (hOAT3/SLC22A8) is predominantly expressed in the
proximal tubules of the kidney and plays a major role in the urinary excretion of a variety of …

Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier

R Kikuchi, H Kusuhara, D Sugiyama… - Journal of Pharmacology …, 2003 - ASPET
The role of rat organic anion transporter 3 (rOat3; Slc22a8) in the efflux transport at the blood-brain
barrier (BBB) was characterized. The expression of rOat1, rOat2, and rOat3 in the …

[HTML][HTML] Precipitation nowcasting with three-dimensional space–time extrapolation of dense and frequent phased-array weather radar observations

S Otsuka, G Tuerhong, R Kikuchi… - Weather and …, 2016 - journals.ametsoc.org
Bluestein, HB, French MM, PopStefanija I., Bluth RT, and Knorr JB, 2010: A mobile, phased-
array Doppler radar for the study of severe convective storms. Bull. Amer. Meteor. Soc., 91 …

Prediction of clinical drug–drug interactions of veliparib (ABT-888) with human renal transporters (OAT1, OAT3, OCT2, MATE1, and MATE2K)

R Kikuchi, Y Lao, DAJ Bow, WJ Chiou… - Journal of …, 2013 - Elsevier
Veliparib (ABT-888) is largely eliminated as parent drug in human urine (70% of the dose).
Renal unbound clearance exceeds glomerular filtration rate, suggesting the involvement of …

In vitro P-glycoprotein efflux ratio can predict the in vivo brain penetration regardless of biopharmaceutics drug disposition classification system class

R Kikuchi, SM de Morais, JC Kalvass - Drug Metabolism and Disposition, 2013 - ASPET
P-glycoprotein (P-gp) is expressed at the blood-brain barrier (BBB) and restricts the penetration
of its substrates into the central nervous system (CNS). In vitro substrate assessment for …

Transcriptional regulation of human and mouse organic anion transporter 1 by hepatocyte nuclear factor 1 α/β

T Saji, R Kikuchi, H Kusuhara, I Kim, FJ Gonzalez… - … of Pharmacology and …, 2008 - ASPET
Organic anion transporter 1 (OAT1/SLC22A6) is predominantly expressed in the proximal
tubules of the kidney. Cumulative studies have shown its critical role in the tubular secretion of …

Epigenetic regulation of organic anion transporting polypeptide 1B3 in cancer cell lines

S Imai, R Kikuchi, Y Tsuruya, S Naoi, S Nishida… - Pharmaceutical …, 2013 - Springer
Purpose The expression of a multispecific organic anion transporter, OATP1B3/SLCO1B3,
is associated with clinical prognosis and survival of cancer cells. The aims of present study …

Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 α/β and DNA methylation

R Kikuchi, H Kusuhara, N Hattori, I Kim, K Shiota… - Molecular …, 2007 - ASPET
Expression of Urate transporter 1 (URAT1/SLC22A12) is restricted to the proximal tubules in
the kidney, where it is responsible for the tubular reabsorption of urate. To elucidate the …

Regulation of tissue-specific expression of renal organic anion transporters by hepatocyte nuclear factor 1 α/β and DNA methylation

L Jin, R Kikuchi, T Saji, H Kusuhara… - Journal of Pharmacology …, 2012 - ASPET
We have reported previously that the kidney- and liver-specific expression of transporters in
mice involves the coordinated regulation by hepatocyte nuclear factor 1 (HNF1) and DNA …