We have recently discovered a class of depsipeptides in a Caribbean tunicate of the family
Didemnidae (a species of the genus Trididemnum) 1 andhave reported their isolation, …

(14) Peaks upfield of 3.4 ppm are due either to nPe4N+ or CH3CN. Multiple! at~ 7.5 ppm is
due to PhSSPh. The UV-vis spectrum of the solid dissolved in DMF is identical to that …

Screening for soil cultures producing agents displaying both cytotoxic activity against L1210
cells in culture and in vivo activity against P388 leukemia in mice afforded a culture, …

A series of novel spirocyclic benzopyran imidazolones were synthesized as rigid analogues
of cromakalim. These compounds cause a dose-dependent membrane hyperpolarization of …

The crystal and molecular structure of a potent antitumor agent, CC-1065 (C37H33N708),
has been determined, and circular dichroism studies have demonstrated a strong interaction …

Proton magnetic resonance spectra were recorded on a Varian XL-100-15 spectrometer
operating at 100 MHz. Solutions (ca. 0.4 ml, ca. 0.25 M) of the compounds in D2O were used. …

Ptilocaulin nitrate, isolated as colorless crystals (mp 183-185 C, C15H26N3+ NCV5a and
isoptilocaulin nitrate, isolated as a yellow oil containing ca. 10% of ptilocaulin nitrate (…

3 considered to be in equilibrium with l, 15 to yield the radical 5 and benzophenone ketyl.
From the radical 5 thusformed, the ß hydrogen is removed by the ketyl radical to afford 2 (…

Sir: In the course of screening for soil cultures producing agents displaying both cytotoxic
activity against L1210 cells in culture and in vivo activity against P388 leukemia in mice, a …

A large number of pathological conditionshave been associated with elevated levels of
reactiveoxygen species1-4 (superoxide, hydrogen peroxide, hydroxyl radical, singlet oxygen), …