Martinelline and martinellic acid, novel G-protein linked receptor antagonists from the tropical plant Martinella iquitosensis (Bignoniaceae)

…, PS Anderson, SM Pitzenberger… - Journal of the …, 1995 - ACS Publications
Twonovel pyrroloquinoline alkaloids, martinelline (1) and martinellic acid (2), were isolated
from an organic extract of Martinella iquitosensis roots. The ethnobotanical use of the two …

High fatty acid content in rabbit serum is responsible for the differentiation of osteoblasts into adipocyte‐like cells

…, KM Witherup, SM Pitzenberger… - Journal of Bone and …, 1998 - academic.oup.com
Osteoblasts and adipocytes originate from common mesenchymal precursors. With aging,
there is a decrease in osteoprogenitor cells that parallels an increase of adipocytes in bone …

[PDF][PDF] In vitro and in vivo biotransformation of simvastatin, an inhibitor of HMG CoA reductase.

…, SR Prakash, HG Ramjit, SM Pitzenberger… - Drug Metabolism and …, 1990 - Citeseer
IN WTRO AND IN WVO BIOTRANSFORMATION OF SIMVASTATIN, AN INHIBITOR OF HMG
CoA REDUCTASE Page 1 In vwo Lactone form (SV) Send reprint requests to: Dr. Stanley …

Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase

…, BE Libby, KT Nguyen, SM Pitzenberger… - Journal of medicinal …, 1999 - ACS Publications
Novel potent and selective diarylimidazole inhibitors of p38 MAP (mitogen-activated protein)
kinase are described which have activity in both cell-based assays of tumor necrosis factor-…

Transglutaminase inhibition by 2-[(2-oxopropyl) thio] imidazolium derivatives: mechanism of factor XIIIa inactivation

…, DC Remy, JJ Baldwin, SM Pitzenberger… - Biochemistry, 1994 - ACS Publications
Revised Manuscript Received May 16, 19948 abstract: The physiologic role of several
transglutaminases could be more precisely defined with the development of specific inhibitors for …

Chemical synthesis of echistatin, a potent inhibitor of platelet aggregation from Echis carinatus: synthesis and biological activity of selected analogs.

…, RM Freidinger, SM Pitzenberger… - Proceedings of the …, 1989 - National Acad Sciences
Echistatin, a polypeptide from the venom of the saw-scaled viper, Echis carinatus, containing
49 amino acids and 4 cystine bridges was synthesized by solid-phase methodology in 4% …

[PDF][PDF] Biotransformation of lovastatin. I. Structure elucidation of in vitro and in vivo metabolites in the rat and mouse.

KP Vyas, PH Kari, SM Pitzenberger, RA Halpin… - Drug metabolism and …, 1990 - Citeseer
TABLE mM). DISPOSITION OF DOPAMINE PRODRUG TA-870 mM) mM) HVA 750 PB/MeOH
DEC-TA-870 CH3CN ± SE of nine humans. at -70#{176}Cun Page 1 H0’-” NH HCI CH0C0O …

Characterization of a solid state reaction product from a lyophilized formulation of a cyclic heptapeptide. A novel example of an excipient-induced oxidation

…, MJ Bogusky, AB Coddington, SM Pitzenberger - Pharmaceutical …, 1996 - Springer
Purpose. To elucidate the structure of a degradation product arising from a lyophilized
formulation of a cyclic heptapeptide, and to provide a mechanism to account for its formation. …

Proton NMR assignments and secondary structure of the snake venom protein echistatin

Y Chen, SM Pitzenberger, VM Garsky, PK Lumma… - Biochemistry, 1991 - ACS Publications
Revised Manuscript Received August 26, 1991 abstract: The snake venom protein echistatin
is a potent inhibitor of platelet aggregation. The inhibitory properties of echistatin have …

Solution structure of the cytoplasmic domain of phospholamban: phosphorylation leads to a local perturbation in secondary structure

RJ Mortishire-Smith, SM Pitzenberger, CJ Burke… - Biochemistry, 1995 - ACS Publications
Revised Manuscript Received April 14, 1995® abstract: Peptides representing the N-terminal
domain (la) of the cardiac sarcoplasmic reticulum protein phospholamban (residues 1—25 …