Voriconazole is a broad spectrum antifungal agent for treating life-threatening fungal
infections. Its clearance is approximately 3-fold higher in children compared with adults. …

Voriconazole is a potent second-generation triazole antifungal agent with broad-spectrum
activity against clinically important fungi. It is cleared predominantly via metabolism in all …

Micafungin, a new echinocandin antifungal agent, has been used widely for the treatment of
various fungal infections in human populations. Micafungin is predominantly cleared by …

The purpose of the present study was to elucidate the transport mechanisms responsible for
elimination of micafungin, a new semisynthetic echinocandin antifungal agent, which is …

P-glycoprotein (P-gp) plays an important role in determining net brain uptake of fexofenadine.
Initial in vivo experiments with 24-h subcutaneous osmotic minipump administration …

Serving as a practical handbook about ADMET for drug therapy, this book presents effective
technologies, methods, applications, data interpretation, and decision-making tactics for …

Partial purification of ribonucleoside diphosphate reductase from rabbit bone marrow was
achieved by size exclusion HPLC of the crude homogenate. This step, requiring <15 min, led …

Substituted metalloporphyrins, in addition to their use as pharmacological agents, are used
to investigate metabolic pathways by inhibiting cytochrome P-450. We have examined the …

… of SB versus for-cause biopsies (FCBs). The study population was 47.1% male and 54.7%
Hispanic, and 31% received living donor grafts. Our data suggest that patients in the SB …

Rice cooking and eating qualities (CEQ) are mainly determined by cooked rice textural
parameters and starch physicochemical properties. However, the genetic bases of grain texture …