A novel type of short-and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria.

SE Alexson, J Nedergaard - Journal of Biological Chemistry, 1988 - Elsevier
Acyl-CoA hydrolase activities were studied in brown adipose tissue from hamsters. A latent
activity was observed in isolated mitochondria. Two peaks of activity were clearly visible in …

Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen

…, A Higginbottom, S Allen, T Beaujeux, SE Alexson… - Brain, 2006 - academic.oup.com
There is now compelling evidence of mitochondrial dysfunction in motor neuron disease (MND),
but the molecular basis of these abnormalities is unknown. It is also unclear whether the …

Metabolism of prostaglandin F2 alpha in Zellweger syndrome. Peroxisomal beta-oxidation is a major importance for in vivo degradation of prostaglandins in humans.

U Diczfalusy, BF Kase, SE Alexson… - The Journal of clinical …, 1991 - Am Soc Clin Investig
We have recently shown in vitro that the peroxisomal fraction of a rat liver homogenate has
the highest capacity to beta-oxidize prostaglandins. In order to evaluate the relative …

Partial disassembly of peroxisomes.

SE Alexson, Y Fujiki, H Shio, PB Lazarow - The Journal of cell biology, 1985 - rupress.org
Rat liver peroxisomes were subjected to a variety of procedures intended to partially disassemble
or damage them; the effects were analyzed by recentrifugation into sucrose gradients, …

Amino acid sequence similarities of the mitochondrial short chain delta 3, delta 2-enoyl-CoA isomerase and peroxisomal multifunctional delta 3, delta 2-enoyl-CoA …

…, M Vihinen, PI Mäntsälä, SE Alexson… - Journal of Biological …, 1991 - Elsevier
We report the isolation and characterization of a cDNA encoding the mitochondrial short
chain delta 3, delta 2-enoyl-CoA isomerase from rat liver. Tryptic fragments of the purified …

[HTML][HTML] Peroxisomal chain-shortening of prostaglandin F2 alpha.

U Diczfalusy, SE Alexson - Journal of Lipid Research, 1988 - Elsevier
We have recently reported that prostaglandin F2 alpha can be chain-shortened by isolated
rat liver peroxisomes. In the present study it is further established by cell fractionation …

Identification of metabolites from peroxisomal beta-oxidation of prostaglandins.

U Diczfalusy, SE Alexson - Journal of lipid research, 1990 - Elsevier
We have recently shown that isolated rat liver peroxisomes can chain-shorten prostaglandin
F2 alpha and prostaglandin E2 to tetranor-metabolites. In the present report dinor-…

The presence of acyl-CoA hydrolase in rat brown-adipose-tissue peroxisomes

SE Alexson, H Osmundsen, RK Berge - Biochemical Journal, 1989 - portlandpress.com
The subcellular distribution of acyl-CoA hydrolase was studied in rat brown adipose tissue,
with special emphasis on possible peroxisomal localization. Subcellular fractionation by …

[HTML][HTML] Molecular cloning and identification of a rat serum carboxylesterase expressed in the liver.

SE Alexson, TH Finlay, U Hellman, LT Svensson… - Journal of Biological …, 1994 - Elsevier
We have cloned and sequenced a carboxylesterase from rat liver and purified the corresponding
protein from rat blood. The cDNA encodes the entire mature serum esterase protein. It …

Peroxisomal chain-shortening of thromboxane B2: evidence for impaired degradation of thromboxane B2 in Zellweger syndrome

…, O Vesterqvist, BF Kase, E Lund, SE Alexson - Journal of lipid …, 1993 - Elsevier
We have shown that rat liver peroxisomes can chain-shorten prostaglandins to dinor- and
tetranor-metabolites. In a recent in vivo study we could demonstrate that peroxisomes are of …