User profiles for S. H. Tam
Susan TamVP, Discovery Research Verified email at tavotek.com Cited by 3017 |
Higher levels of sialylated Fc glycans in immunoglobulin G molecules can adversely impact functionality
BJ Scallon, SH Tam, SG McCarthy, AN Cai… - Molecular immunology, 2007 - Elsevier
Although it is now clear that certain Fc glycan structures on immunoglobulin G (IgG) antibodies
(Abs) can have a dramatic influence on binding to selected Fcγ receptors (FcγR) and on …
(Abs) can have a dramatic influence on binding to selected Fcγ receptors (FcγR) and on …
Abciximab (ReoPro, Chimeric 7E3 Fab) Demonstrates Equivalent Affinity and Functional Blockade of Glycoprotein IIb/IIIa and αvβ3 Integrins
SH Tam, PM Sassoli, RE Jordan, MT Nakada - Circulation, 1998 - Am Heart Assoc
Background—Large, randomized, and blinded clinical trials (EPIC, EPILOG, and CAPTURE)
have demonstrated that abciximab (ReoPro, chimeric 7E3 Fab) markedly reduces …
have demonstrated that abciximab (ReoPro, chimeric 7E3 Fab) markedly reduces …
Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge
…, O Vafa, D Petrone, SH Tam… - Proceedings of the …, 2009 - National Acad Sciences
The successful elimination of pathogenic cells and microorganisms by the humoral immune
system relies on effective interactions between host immunoglobulins and Fcγ receptors on …
system relies on effective interactions between host immunoglobulins and Fcγ receptors on …
[HTML][HTML] Human and non-human primate intestinal FcRn expression and immunoglobulin G transcytosis
…, S Thompson, AL Kauffman, Z Yan, SH Tam… - Pharmaceutical …, 2014 - Springer
Purpose To evaluate transcytosis of immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn)
in adult primate intestine to determine whether this is a means for oral delivery of …
in adult primate intestine to determine whether this is a means for oral delivery of …
CNTO 859, a humanized anti‐tissue factor monoclonal antibody, is a potent inhibitor of breast cancer metastasis and tumor growth in xenograft models
Thromboembolic complications are frequently associated with advanced cancer. Interestingly,
one of the major initiators of blood coagulation, tissue factor (TF), is reported to be …
one of the major initiators of blood coagulation, tissue factor (TF), is reported to be …
Engineering host cell lines to reduce terminal sialylation of secreted antibodies
MF Naso, SH Tam, BJ Scallon, TS Raju - MAbs, 2010 - Taylor & Francis
Covalently-linked glycans on proteins have many functional roles, some of which are still not
completely understood. Antibodies have a very specific glycan modification in the Fc region …
completely understood. Antibodies have a very specific glycan modification in the Fc region …
Abundance, diversity, and regulation of mRNA sequence sets in soybean embryogenesis
RB Goldberg, G Hoschek, SH Tam, GS Ditta… - Developmental …, 1981 - Elsevier
Soybean embryo mRNA populations were compared with respect to complexity, abundance
distribution, and sequence representation. RNA-excess hybridization experiments with …
distribution, and sequence representation. RNA-excess hybridization experiments with …
Correlations between pharmacokinetics of IgG antibodies in primates vs. FcRn-transgenic mice reveal a rodent model with predictive capabilities
SH Tam, SG McCarthy, K Brosnan, KM Goldberg… - MAbs, 2013 - Taylor & Francis
Transgenic mice expressing human neonatal Fc receptor (FcRn) instead of mouse FcRn
are available for IgG antibody pharmacokinetic (PK) studies. Given the interest in a rodent …
are available for IgG antibody pharmacokinetic (PK) studies. Given the interest in a rodent …
Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model
Background. Tissue factor (TF) expression on islets can result in an instant blood-mediated
inflammatory reaction (IBMIR) that contributes to early islet loss. We tested whether …
inflammatory reaction (IBMIR) that contributes to early islet loss. We tested whether …
[HTML][HTML] Functional, biophysical, and structural characterization of human IgG1 and IgG4 Fc variants with ablated immune functionality
Engineering of fragment crystallizable (Fc) domains of therapeutic immunoglobulin (IgG)
antibodies to eliminate their immune effector functions while retaining other Fc characteristics …
antibodies to eliminate their immune effector functions while retaining other Fc characteristics …