Anacetrapib is a novel cholesteryl ester transfer protein inhibitor being developed for the
treatment of primary hypercholesterolemia and mixed dyslipidemia. The absorption, distribution…

The objective of the current study was to evaluate the mechanism of absorption and
metabolism of a PEGylated peptide, MRL-1 (46 kDa), after sc dosing in dogs and rats. Thoracic …

The synthesis of the first high specific activity S-35-labeled hERG radioligand, [ 35 S]MK-0499,
for use in HTS assays of drug candidates for hERG interaction is described. The …

We have developed an FT-IR method, using a Spectra-Tech Monit-IR 400 systems, to monitor
off-line the completion of a reaction in real-time. The reaction is moisture-sensitive and …

Determining the radiochemical purity of low specific activity tracers (ca. 1μCi/mg) can be
challenging due to low signal to noise in the radiochromatogram. The result can be an …

Anacetrapib is a novel cholesteryl ester transfer protein (CETP) inhibitor being developed
for the treatment of primary hypercholesterolemia and mixed dyslipidemia. The absorption, …

The cytochromes P-450 (CYP) constitute a superfamily of heme-containing enzymes that are
involved in the metabolism of a wide variety of endogenous and exogenous compounds. 1 …

Human mobility has been vigorously debated as a key factor for the spread of bronze technology
and profound changes in burial practices as well as material culture in central Europe …

Revealing and understanding the mechanisms behind social inequality in prehistoric
societies is a major challenge. By combining genome-wide data, isotopic evidence, and …

Various techniques of measurements: differential scanning calorimetry (DSC), thermogravimetric
analysis (TGA), differential thermal analysis (DTA), infrared (IR), far infrared (FIR) and …