The initial metabolism of ifosfamide (IFO) consists of two different pathways, which lead to
the alkylating metabolite 4-hydroxy-IFO and to chloroacetaldehyde (CAA). CAA has been …

Metabolic activation of ifosfamide (IFO) leads to the active 4-hydroxy-metabolite and to a
substantial liberation of chloroacetaldehyde (CAA). CAA has been presumed responsible for …

Background: The ifosfamide metabolite chloroacetaldehyde had been made responsible for
side effects only. We found in previous studies a strong cytotoxicity on human MX-1 tumor …

OBJECTIVE: This study focuses on the pharmacokinetics of trofosfamide (TRO) and metabolites
after oral administration of TRO. METHODS: Twelve patients with solid tumors and non-…

Dexamethasone induces the hepatic cytochrome P450 3A and, therefore, is predicted to
change the pharmacokinetics, activities, and side effects of drugs metabolized by cytochrome …

A field study of coral bleaching and coral communities was undertaken spanning 8 countries
and~ 35 of latitude in 2005. This was combined with studies in southern Kenya and …

Campylobacter jejuni is a leading cause of human gastroenteritis worldwide. This study aimed
at a better understanding of the genetic diversity of this pathogen disseminated in Japan. …

Satellite and compiled in situ observations of sea surface temperatures have greatly increased
the ability to detect anomalous and persistent warm water and are being widely used to …

Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) is a high-risk subgroup of T-lineage
ALL characterized by specific stem cell and myeloid features. In adult ETP-ALL, no …

Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized
by distinct genetic alterations and inferior prognosis in children and younger adults. The …