The pharmacokinetics of 1-β-d-arabinofuranosylcytosine (Ara-C) and 1-β-d-arabinofuranosyluracil
(Ara-U) are related to enzyme kinetics in vitro in mice, monkeys, dogs and humans by …

The disposition of 14 C‐labeled decabromobiphenyl ether (DBBE) in male Fischer rats dosed
by feeding (0.025–5.0% of the diet) or intravenously (1 mg/kg) was determined. For rats …

… EL DAREER SM, and MELLETT LB. The estimation of" Hvincristine (" H-VCR) and its …
MELLETT LB, and EL DAREER SM. Metabolic disposition of " H-vincristine sulfate (" H-VCR…

Administration to rats of oral doses of [ 14 C]‐2‐hydroxy‐4‐methoxybenzophenone (HMB)
in the range of 3.01–2570 mg/kg revealed that a dose‐dependent elimination process was …

A chromatographic procedure that allows measurement of [3H] prednisone and [3H]
prednisolone in biologic fluids and tissues was developed and used to determine some of the …

Abstract Analysis of blood from a dog given a 400 mg/m 2 dose of 9-β-d-arabinofuranosyl-2-fluoroadenine
(2-F-araA) led to the identification of parent drug and a major metabolite, 9-β-d…

MATERIALS AND METHODS 2-F-araAMP was synthesized by Dr. JA Montgomery of the
Southern Research Institute (Birmingham, AL) and tritiated by New England Nuclear Corp (…

To determine the metabolic disposition of [ 14 C]‐2‐mercaptobenzothiazole (MBT) and [ 14
C]‐2‐mercaptobenzothiazole disulfide (MBTS), male and female rats were dosed topically. …

Materials and Methods EHNA and [8-’4C] EHNA were provided by the Drug Development
Branch, National Cancer Institute. Bio-Solv BBS-3 solubilizer was purchased from Beckman …

The pharmacologic disposition of [methyl-14C] 5-methyltetrahydrohomofolate (MTHHF) and
[³H] methotrexate (MTX) has been studied in rats after iv doses of 25 mg/kg. Thin-layer …