Acetaminophen‐induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition
JA Hinson, AB Reid, SS McCullough… - Drug metabolism …, 2004 - Taylor & Francis
Large doses of the analgesic acetaminophen cause centrilobular hepatic necrosis in man
and in experimental animals. It has been previously shown that acetaminophen is …
and in experimental animals. It has been previously shown that acetaminophen is …
Mechanisms of acetaminophen-induced hepatotoxicity: role of oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes
AB Reid, RC Kurten, SS McCullough, RW Brock… - … of Pharmacology and …, 2005 - ASPET
Freshly isolated mouse hepatocytes were used to determine the role of mitochondrial
permeability transition (MPT) in acetaminophen (APAP) toxicity. Incubation of APAP (1 mM) with …
permeability transition (MPT) in acetaminophen (APAP) toxicity. Incubation of APAP (1 mM) with …
Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation
LP James, SS McCullough, LW Lamps… - Toxicological …, 2003 - academic.oup.com
The relationship between acetaminophen (APAP) reactive metabolite formation, nitrotyrosine
(NT) production, and cytokine elevation in APAP toxicity was investigated. Mice were …
(NT) production, and cytokine elevation in APAP toxicity was investigated. Mice were …
Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance …
KL Muldrew, LP James, L Coop, SS McCullough… - Drug metabolism and …, 2002 - ASPET
Acetaminophen-induced hepatotoxicity has been attributed to covalent binding of the
reactive metaboliteN-acetyl-p-benzoquinone imine to cysteine groups on proteins as an …
reactive metaboliteN-acetyl-p-benzoquinone imine to cysteine groups on proteins as an …
Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress
LP James, SS McCullough, TR Knight… - Free radical …, 2003 - Taylor & Francis
Previous data have indicated that activated macrophages may play a role in the mediation
of acetaminophen toxicity. In the present study, we examined the significance of superoxide …
of acetaminophen toxicity. In the present study, we examined the significance of superoxide …
Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity
B Donahower, SS McCullough… - American Journal …, 2006 - journals.physiology.org
VEGF or VEGF-A is a major regulator of angiogenesis and has been recently shown to be
important in organ repair. The potential role of VEGF in acetaminophen (APAP)-induced …
important in organ repair. The potential role of VEGF in acetaminophen (APAP)-induced …
Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity
BC Donahower, SS McCullough, L Hennings… - … of Pharmacology and …, 2010 - ASPET
We reported previously that vascular endothelial growth factor (VEGF) was increased in
acetaminophen (APAP) toxicity in mice and treatment with a VEGF receptor inhibitor reduced …
acetaminophen (APAP) toxicity in mice and treatment with a VEGF receptor inhibitor reduced …
[HTML][HTML] Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk
…, DJ Johann, FD Allard, EU Yee, SS McCullough… - … Pharmaceutica Sinica B, 2021 - Elsevier
We previously demonstrated that endogenous phosphatidic acid (PA) promotes liver
regeneration after acetaminophen (APAP) hepatotoxicity. Here, we hypothesized that exogenous …
regeneration after acetaminophen (APAP) hepatotoxicity. Here, we hypothesized that exogenous …
[HTML][HTML] Paradoxical patterns of sinusoidal obstruction syndrome-like liver injury in aged female CD-1 mice triggered by cannabidiol-rich cannabis extract and …
…, M Clemens, JH Vazquez, SS McCullough… - Molecules, 2019 - mdpi.com
The goal of this study was to investigate the potential for a cannabidiol-rich cannabis extract
(CRCE) to interact with the most common over-the-counter drug and the major known cause …
(CRCE) to interact with the most common over-the-counter drug and the major known cause …
[HTML][HTML] Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes
…, KJ Krager, N Aykin-Burns, SS McCullough… - Toxicology reports, 2017 - Elsevier
The hepatotoxicity of acetaminophen (APAP) occurs by initial metabolism to N-acetyl-p-benzoquinone
imine which depletes GSH and forms APAP-protein adducts. Subsequently, the …
imine which depletes GSH and forms APAP-protein adducts. Subsequently, the …