User profiles for S. T. Caldwell
stuart caldwellResearch Associate, School of Chemistry, University of Glasgow Verified email at glasgow.ac.uk Cited by 3418 |
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage
function, but its precise mechanism of action remains poorly understood 1 , 2 , 3 . Here we …
function, but its precise mechanism of action remains poorly understood 1 , 2 , 3 . Here we …
Highly stable tetrathiafulvalene radical dimers in [3] catenanes
…, E Tkatchouk, MT Colvin, R Carmielli, ST Caldwell… - Nature …, 2010 - nature.com
Two [3]catenane ‘molecular flasks’ have been designed to create stabilized, redox-controlled
tetrathiafulvalene (TTF) dimers, enabling their spectrophotometric and structural properties …
tetrathiafulvalene (TTF) dimers, enabling their spectrophotometric and structural properties …
Bioavailability of [2-14C]Quercetin-4′-glucoside in Rats
…, C Auger, PL Teissedre, ST Caldwell… - Journal of agricultural …, 2008 - ACS Publications
[2- 14 C]Quercetin-4′-glucoside (4 mg/kg body weight) was fed by gavage to rats housed
in metabolic cages, and over an ensuing 72 h period, radiolabeled products in body tissues, …
in metabolic cages, and over an ensuing 72 h period, radiolabeled products in body tissues, …
Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation
During heart transplantation, storage in cold preservation solution is thought to protect the
organ by slowing metabolism, providing osmotic support and minimizing ischaemia–…
organ by slowing metabolism, providing osmotic support and minimizing ischaemia–…
[HTML][HTML] Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation
Mitochondrial oxidative stress, mitochondrial dysfunction, or both have been implicated in
insulin resistance. However, disentangling the individual roles of these processes in insulin …
insulin resistance. However, disentangling the individual roles of these processes in insulin …
Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid …
CJ Bennett, ST Caldwell, DB McPhail… - Bioorganic & medicinal …, 2004 - Elsevier
The flavonol myricetin, reacts with oxygen-centred galvinoxyl radicals 28 times faster than d-α-tocopherol
(vitamin E), the main lipid-soluble antioxidant in biological membranes. …
(vitamin E), the main lipid-soluble antioxidant in biological membranes. …
Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore
S Chalmers, ST Caldwell, C Quin… - Journal of the …, 2012 - ACS Publications
Depolarization of an individual mitochondrion or small clusters of mitochondria within cells
has been achieved using a photoactivatable probe. The probe is targeted to the matrix of the …
has been achieved using a photoactivatable probe. The probe is targeted to the matrix of the …
Determination of Flavonol Metabolites in Plasma and Tissues of Rats by HPLC−Radiocounting and Tandem Mass Spectrometry Following Oral Ingestion of [2-14C] …
W Mullen, BA Graf, ST Caldwell… - Journal of agricultural …, 2002 - ACS Publications
Epidemiological studies suggest that consumption of flavonol-rich diets decreases the risk
of developing heart disease and certain cancers. Recent studies have detected flavonol …
of developing heart disease and certain cancers. Recent studies have detected flavonol …
[PDF][PDF] MitoNeoD: a mitochondria-targeted superoxide probe
Mitochondrial superoxide (O 2 ⋅− ) underlies much oxidative damage and redox signaling.
Fluorescent probes can detect O 2 ⋅− , but are of limited applicability in vivo, while in cells …
Fluorescent probes can detect O 2 ⋅− , but are of limited applicability in vivo, while in cells …
[HTML][HTML] Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury
…, Y Tsujihata, A Logan, O Sauchanka, ST Caldwell… - Redox Biology, 2022 - Elsevier
Mitochondria-targeted H 2 S donors are thought to protect against acute ischemia-reperfusion
(IR) injury by releasing H 2 S that decreases oxidative damage. However, the rate of H 2 S …
(IR) injury by releasing H 2 S that decreases oxidative damage. However, the rate of H 2 S …