A rat model of bone cancer pain

SJ Medhurst, K Walker, M Bowes, BL Kidd, M Glatt… - Pain, 2002 - journals.lww.com
This study describes the first known model of bone cancer pain in the rat. Sprague–Dawley
rats receiving intra-tibial injections of syngeneic MRMT-1 rat mammary gland carcinoma cells …

The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain

KM Walker, L Urban, SJ Medhurst, S Patel… - Journal of pharmacology …, 2003 - ASPET
… with an accuracy of 0.1 s. Withdrawal latencies were measured with a beam intensity of
22.9 for rats and mice and 50 for guinea pigs, with a cut-off of 32 s. Measurements were made …

Personality correlates of academic seminar behaviour: A study of four instruments

A Furnham, S Medhurst - Personality and individual differences, 1995 - Elsevier
… produced equivocal results when attempting to test Eysenck’s theory. Kline and Gale (1971) …
s age and personality scores. There appears to be evidence both in favour of Anthony’s

Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain

SJ Medhurst, SD Collins, A Billinton, S Bingham… - Pain, 2008 - journals.lww.com
Several studies have implicated a potential role for histamine H 3 receptors in pain processing,
although the data are somewhat conflicting. In the present study we investigated the …

Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat

SJR Elmes, LA Winyard, SJ Medhurst, NM Clayton… - Pain, 2005 - Elsevier
The aim of the present study was to investigate the effects of cannabinoid agonists on
established inflammatory hyperalgesia. We have compared the effects of pre-administration …

Disease modifying and anti-nociceptive effects of the bisphosphonate, zoledronic acid in a model of bone cancer pain

…, SJ Medhurst, BL Kidd, M Glatt, M Bowes, S Patel… - Pain, 2002 - Elsevier
… A single trial consisted of six to eight applications of the filament within a 2–3 s period. At …
a separate transducer pad, which recorded over 3 s the distribution of the animals' body weight …

Discovery and structure–activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor

…, CL Lejeune, DG Livermore, SJ Medhurst… - Bioorganic & medicinal …, 2010 - Elsevier
A computational lead-hopping exercise identified compound 4 as a structurally distinct P2X
7 receptor antagonist. Structure–activity relationships (SAR) of a series of pyroglutamic acid …

An animal model of chronic inflammatory pain: pharmacological and temporal differentiation from acute models

AW Wilson, SJ Medhurst, CI Dixon, NC Bontoft… - European Journal of …, 2006 - Elsevier
Clinically, inflammatory pain is far more persistent than that typically modelled pre-clinically,
with the majority of animal models focussing on short-term effects of the inflammatory pain …

Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced …

…, T Heslop, WD Hirst, SJ Medhurst, S Ociepka… - Biochemical …, 2007 - Elsevier
… the inhibitory stimulus was evaluated 24 h post-training by returning the animal into the light
chamber and recording their latency to enter the dark chamber and a criterion time of 600 s

Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat

A Fox, S Medhurst, JP Courade, M Glatt, J Dawson… - Pain, 2004 - Elsevier
Chronic pain resulting from metastatic bone cancer remains poorly understood and resistant
to treatment. Here we have examined the effect of the novel COX-2 enzyme inhibitor …