[HTML][HTML] The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response
…, E Leinonen, YJ Liou, T Mushiroda, S Nonen… - Translational …, 2015 - nature.com
Response to treatment with selective serotonin reuptake inhibitors (SSRIs) varies considerably
between patients. The International SSRI Pharmacogenomics Consortium (ISPC) was …
between patients. The International SSRI Pharmacogenomics Consortium (ISPC) was …
Connective tissue growth factor induces cardiac hypertrophy through Akt signaling
…, M Obana, M Takai, T Mohri, S Nonen… - Biochemical and …, 2008 - Elsevier
… Non-attached cells were collected as cardiomyocytes and cultured in Dulbecco’s modified
Eagle’s medium/Ham’s F-12 (DMEM/F-12) containing 5% neonatal calf serum (NCS). More …
Eagle’s medium/Ham’s F-12 (DMEM/F-12) containing 5% neonatal calf serum (NCS). More …
Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients
…, Y Kouno, T Tanabe, Y Masunaga, S Nonen… - European journal of …, 2009 - Springer
… Warfarin is a racemic mixture of S− and R−warfarin, with S-warfarin approximately three to
five times more potent as an anticoagulant than R-warfarin [2, 3]. S-warfarin is metabolized …
five times more potent as an anticoagulant than R-warfarin [2, 3]. S-warfarin is metabolized …
Chronic heart failure: β-blockers and pharmacogenetics
J Azuma, S Nonen - European journal of clinical pharmacology, 2009 - Springer
… Individualized drug therapy means that the choice of the drug and the choice of initial drug
dosing regimens are selected based on the patient’s individual requirements, which may …
dosing regimens are selected based on the patient’s individual requirements, which may …
Polymorphisms of CYP2D6 gene and gefitinib-induced hepatotoxicity
…, S Nonen, Y Namba, M Mori, S Yokota, S Minami… - Clinical lung cancer, 2013 - Elsevier
… with gefitinib, and none of them experienced hepatotoxicity again, irrespective of CYP2D6
genotypes. … In our study, none of 17 patients with the CYP2D6 allele *5 or *10 experienced …
genotypes. … In our study, none of 17 patients with the CYP2D6 allele *5 or *10 experienced …
[HTML][HTML] Association of the polygenic scores for personality traits and response to selective serotonin reuptake inhibitors in patients with major depressive disorder
…, E Leinonen, YJ Liou, T Mushiroda, S Nonen… - Frontiers in …, 2018 - frontiersin.org
… In the cross-trait meta-analyses, we applied the O’Brien’s (OB) method and the direct
Linear Combination of dependent test statistics (dLC) approach (39, 44, 45), which are …
Linear Combination of dependent test statistics (dLC) approach (39, 44, 45), which are …
MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients
…, M Nishida, S Nonen, Y Fujio, S Kasayama… - Journal of Diabetes and …, 2008 - Elsevier
AIMS: Previously, we have proposed that methylenetetrahydrofolate reductase (MTHFR)
gene polymorphism (C677T) could be a risk factor for diabetic retinopathy. To support our …
gene polymorphism (C677T) could be a risk factor for diabetic retinopathy. To support our …
The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression
…, E Leinonen, YJ Liou, T Mushiroda, S Nonen… - Journal of Neural …, 2019 - Springer
… In the meta-analyses, we applied the O’Brien’s (OB) method and the direct Linear
Combination of dependent test statistics (dLC) approach, which are implemented in the C ++ eLX …
Combination of dependent test statistics (dLC) approach, which are implemented in the C ++ eLX …
Safe and successful treatment with erlotinib after gefitinib-induced hepatotoxicity: difference in metabolism as a possible mechanism.
T Kijima, T Shimizu, S Nonen, M Furukawa… - Journal of Clinical …, 2011 - europepmc.org
… Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M,
Yoshizawa H, Kinoshita I, Fujita Y, Okinaga S, Hirano H, Yoshimori K, Harada T, Ogura T, Ando …
Yoshizawa H, Kinoshita I, Fujita Y, Okinaga S, Hirano H, Yoshimori K, Harada T, Ogura T, Ando …
Cigarette smoke extract induces CYP2B6 through constitutive androstane receptor in hepatocytes
…, C Sugiura, R Shiga, M Yoshida, S Nonen… - Drug metabolism and …, 2011 - ASPET
Smoking induces a wide range of drug-metabolizing enzymes. Among them, CYP2B6 as
well as CYP1A2 is well known to be up-regulated in smokers. Although the induction of …
well as CYP1A2 is well known to be up-regulated in smokers. Although the induction of …