Absorption, metabolism, and excretion of paliperidone, an atypical antipsychotic, was studied
in five healthy male subjects after a single dose of 1 mg of [ 14 C]paliperidone oral solution …

Two liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS) methods are
described, one for the quantitative determination of risperidone and the enantiomers of its …

Increases in serum prolactin concentrations after administration of risperidone have been
attributed, by some, to the availability of paliperidone in plasma. This double-blind, randomized…

Freshly isolated proximal tubular cells (PTC) of the rat are used to study the uptake of a
prototypical organic cation, tetraethylammonium (TEA) and the influence of other cationic drugs …

Paliperidone extended‐release tablet (paliperidone ER) is a centrally active dopamine D 2
‐ and serotonergic 5‐HT 2A ‐receptor antagonist that is registered for the treatment of …

Objective The effect of trimethoprim, a potent organic cation transport inhibitor, on the
pharmacokinetics (PK) of paliperidone extended‐release tablets (paliperidone ER), an organic …

Ranitidine renal clearance was investigated in the beagle dog with or without concomitant
infusion of cimetidine or probenecid. Ranitidine was excreted mainly by renal tubular secretion…

The renal handling of Cimetidine (pKa «6.8) was studied in the isolated perfused rat kidney (IPK).
Concentrations in the therapeutic range (< 10//g/ml) had little adverse effects on the …

The uptake of Cimetidine was investigated in freshly isolated proximal tubular cells (PTC) of
the rat as well as its interaction with other cationic drugs. The time-dependent uptake of 5 …

An important elimination route of the histamine H 2 antagonist famotidine is active tubular
secretion via the renal organic cation transport system. To characterize the excretion kinetics of …