Developmental expression of the cytosolic sulfotransferases in human liver

S Dubaisi, JA Caruso, R Gaedigk, CA Vyhlidal… - Drug Metabolism and …, 2019 - ASPET
The liver is the predominant organ of metabolism for many endogenous and foreign
chemicals. Cytosolic sulfotransferases (SULTs) catalyze the sulfonation of drugs and other …

Regulation of cytosolic sulfotransferases in models of human hepatocyte development

S Dubaisi, KG Barrett, H Fang, J Guzman-Lepe… - Drug Metabolism and …, 2018 - ASPET
Cytosolic sulfotransferases (SULTs) are expressed during early life and therefore metabolize
endogenous and xenobiotic chemicals during development. Little is currently known about …

Developmental expression of SULT1C4 transcript variants in human liver: implications for discordance between SULT1C4 mRNA and protein levels

S Dubaisi, H Fang, JA Caruso, R Gaedigk… - Drug Metabolism and …, 2020 - ASPET
The cytosolic sulfotransferases (SULTs) metabolize a variety of xenobiotic and endogenous
substrates. Several SULTs are expressed in the fetus, implying that these enzymes have …

Transcriptional regulation of human cytosolic sulfotransferase 1C3 by peroxisome proliferator-activated receptor γ in LS180 human colorectal adenocarcinoma cells

S Dubaisi, H Fang, TA Kocarek, M Runge-Morris - Molecular pharmacology, 2016 - ASPET
Cytosolic sulfotransferase 1C3 (SULT1C3) is the least characterized of the three human
SULT1C subfamily members. Originally identified as an orphan SULT by computational analysis …

In vitro metabolism and drug-drug interaction potential of UTL-5g, a novel chemo-and radioprotective agent

J Wu, J Shaw, S Dubaisi, F Valeriote, J Li - Drug Metabolism and …, 2014 - ASPET
N-(2,4-dichlorophenyl)-5-methyl-1,2-oxazole-3-carboxamide (UTL-5g), a potential chemo-
and radioprotective agent, acts as a prodrug requiring bioactivation to the active metabolite 5-…

Expression and Regulation of SULT1C4 in Human Cells and Tissues

S Dubaisi, H Fang, TA Kocarek… - The FASEB …, 2017 - Wiley Online Library
Cytosolic sulfotransferases (SULTs) are a superfamily of conjugating enzymes that catalyze
the transfer of a sulfonate group from the cofactor 3′‐phosphoadenosine‐5′‐…

The role of uracil-dna glycosylase and folate in the repair of dna

ST Dubaisi - 2012 - digitalcommons.wayne.edu
DNA damage originates from endogenous as well as exogenous sources. UV light and
radiation are among the main sources of exogenous DNA damage. Reactive oxygen species (…

Characterization of Cytosolic Sulfotransferase Expression and Regulation in Human Liver and Intestine

S Dubaisi - 2019 - search.proquest.com
SULTs are conjugation enzymes that can modify the activity of a myriad of foreign and
endogenous molecules. SULT expression was detected in various human tissues, including liver, …

Expression of Multiple Sulfotransferase (SULT) 1C4 Transcript Variants in Developing Human Liver

S Dubaisi, H Fang, R Gaedigk, CA Vyhlidal… - The FASEB …, 2018 - Wiley Online Library
The cytosolic sulfotransferases (SULTs) are conjugating enzymes that catalyze the transfer
of a sulfonate group from the cofactor 3′‐phosphoadenosine‐5′‐phosphosulfate to a …

The role of uracil-DNA glycosylase and folate in the repair of DNA damage

ST Dubaisi - 2012 - search.proquest.com
The impact of DNA damage on genomic integrity has been widely investigated due to its
association with cancer and ageing. DNA repair pathways play a critical role in preserving the …