Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells.

…, M Kawaguchi, S Matsumoto… - Proceedings of the …, 1995 - National Acad Sciences
Although T cells bearing gamma delta T-cell receptors have long been known to be present
in the epithelial lining of many organs, their specificity and function remain elusive. In the …

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

K Kurose, K Gilley, S Matsumoto, PH Watson… - Nature …, 2002 - nature.com
We have recently shown that loss of heterozygosity of specific markers, including those at
10q23, 17p13–p15 and 16q24, can occur in the stromal and epithelial compartments of …

CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation

…, M Okabe, K Takeda, S Akira, S Matsumoto… - The Journal of …, 2001 - rupress.org
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins
(ILs) and interferons. These cytokines exert their biological functions through Janus …

Key bacterial taxa and metabolic pathways affecting gut short-chain fatty acid profiles in early life

…, K Yahagi, T Hara, Y Watanabe, H Matsumoto… - The ISME …, 2021 - academic.oup.com
Infant gut microbiota development affects the host physiology throughout life, and short-chain
fatty acids (SCFAs) are promising key metabolites mediating microbiota-host relationships. …

Segmented filamentous bacteria are indigenous intestinal bacteria that activate intraepithelial lymphocytes and induce MHC class II molecules and fucosyl asialo GM1 …

Y Umesaki, Y Okada, S Matsumoto… - Microbiology and …, 1995 - Wiley Online Library
In ex‐germ‐free mice conventionalized by association with fecal microorganisms, the
induction of major histocompatibility complex class II molecules and fucosylation of asialo GM1 …

Prognostic significance of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in oncologic outcomes of esophageal cancer: a systematic review and meta …

…, A Matsuda, M Miyashita, S Matsumoto… - Annals of surgical …, 2016 - Springer
Background Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR)
have been reported to predict oncologic outcomes in patients with various types of cancer. …

[HTML][HTML] A key genetic factor for fucosyllactose utilization affects infant gut microbiota development

T Matsuki, K Yahagi, H Mori, H Matsumoto… - Nature …, 2016 - nature.com
Recent studies have demonstrated that gut microbiota development influences infants’ health
and subsequent host physiology. However, the factors shaping the development of the …

Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system

Y Umesaki, H Setoyama, S Matsumoto… - Infection and …, 1999 - Am Soc Microbiol
The presence of microflora in the digestive tract promotes the development of the intestinal
immune system. In this study, to evaluate the roles of two types of indigenous microbe, …

[HTML][HTML] Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease

…, CA Moskaluk, S Matsumoto… - The Journal of …, 2001 - Am Soc Clin Investig
We describe here the immunologic characterization of a new mouse strain, SAMP1/Yit, which
spontaneously develops a chronic intestinal inflammation localized to the terminal ileum. …

[HTML][HTML] Growth retardation and early death of β-1, 4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells

M Asano, K Furukawa, M Kido, S Matsumoto… - The EMBO …, 1997 - embopress.org
Carbohydrate chains on a glycoprotein are important not only for protein conformation,
transport and stability, but also for cell–cell and cell–matrix interactions. UDP-Gal: N-…