User profiles for Scott Heyward
 | Scott HeywardBioIVT Verified email at bioivt.com Cited by 2239 |
3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration
Nonclinical testing has served as a foundation for evaluating potential risks and effectiveness
of investigational new drugs in humans. However, the current two‐dimensional (2D) in …
of investigational new drugs in humans. However, the current two‐dimensional (2D) in …
Improved gene transfer into baboon marrow repopulating cells using recombinant human fibronectin fragment CH-296 in combination with interleukin-6, stem cell …
…, J Morris, L Peterson, S Heyward… - Blood, The Journal …, 1998 - ashpublications.org
We have used a competitive repopulation assay in baboons to develop improved methods
for hematopoietic stem cell transduction and have previously shown increased gene transfer …
for hematopoietic stem cell transduction and have previously shown increased gene transfer …
Characterization of differential tissue abundance of major non-CYP enzymes in human
…, SC Khojasteh, BJ Smith, S Heyward… - Molecular …, 2020 - ACS Publications
The availability of assays that predict the contribution of cytochrome P450 (CYP) metabolism
allows for the design of new chemical entities (NCEs) with minimal oxidative metabolism. …
allows for the design of new chemical entities (NCEs) with minimal oxidative metabolism. …
SLC13A5 is a novel transcriptional target of the pregnane X receptor and sensitizes drug-induced steatosis in human liver
…, Q Li, Y Shu, J Zhang, B Hu, S Heyward… - Molecular …, 2015 - ASPET
The solute carrier family 13 member 5 (SLC13A5) is a sodium-coupled transporter that
mediates cellular uptake of citrate, which plays important roles in the synthesis of fatty acids and …
mediates cellular uptake of citrate, which plays important roles in the synthesis of fatty acids and …
Quantitative investigation of irinotecan metabolism, transport, and gut microbiome activation
The anticancer drug irinotecan shows serious dose-limiting gastrointestinal toxicity
regardless of intravenous dosing. Although enzymes and transporters involved in irinotecan …
regardless of intravenous dosing. Although enzymes and transporters involved in irinotecan …
Prospective cohort study of mother‐to‐infant infection and clearance of hepatitis C in rural Egyptian villages
…, S Sharaf, M Hashem, S Heyward… - Journal of medical …, 2009 - Wiley Online Library
Although persistent transmission of hepatitis C virus (HCV) from infected mothers to their
infants is reported in 4–8%, transient HCV perinatal infection also occurs. This prospective …
infants is reported in 4–8%, transient HCV perinatal infection also occurs. This prospective …
Gene transfer into marrow repopulating cells: comparison between amphotropic and gibbon ape leukemia virus pseudotyped retroviral vectors in a competitive …
Many diseases might be treated by gene therapy targeted to the hematopoietic system, but
low rates of gene transfer achieved in humans and large animals have limited the application …
low rates of gene transfer achieved in humans and large animals have limited the application …
Intestinal metabolism of diclofenac by polymorphic UGT2B17 correlates with its highly variable pharmacokinetics and safety across populations
Although the United States and Europe have shifted to the prescription use of oral diclofenac
due to several serious incidences of cardiotoxicity, it is one of the most commonly used over…
due to several serious incidences of cardiotoxicity, it is one of the most commonly used over…
A comparison of total and plasma membrane abundance of transporters in suspended, plated, sandwich-cultured human hepatocytes versus human liver tissue using …
…, X Chu, WG Humphreys, M Liao, S Heyward… - Drug Metabolism and …, 2019 - ASPET
Suspended (SH), plated (PH), and sandwich-cultured hepatocytes (SCH) are commonly
used models to predict in vivo transporter-mediated hepatic uptake (SH or PH) or biliary (SCH) …
used models to predict in vivo transporter-mediated hepatic uptake (SH or PH) or biliary (SCH) …
Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes
C Lynch, Y Pan, L Li, S Heyward, T Moeller… - Toxicology and applied …, 2014 - Elsevier
Objective Accumulating evidence suggests that activation of mouse constitutive androstane
receptor (mCAR) alleviates type 2 diabetes and obesity by inhibiting hepatic …
receptor (mCAR) alleviates type 2 diabetes and obesity by inhibiting hepatic …