Herb–drug interactions: challenges and opportunities for improved predictions
SJ Brantley, AA Argikar, YS Lin, S Nagar… - Drug Metabolism and …, 2014 - ASPET
Supported by a usage history that predates written records and the perception that “natural”
ensures safety, herbal products have increasingly been incorporated into Western health …
ensures safety, herbal products have increasingly been incorporated into Western health …
Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations
Milk thistle (Silybum marianum) is a popular herbal product used for hepatoprotection and
chemoprevention. Two commercially available formulations are the crude extract, silymarin, …
chemoprevention. Two commercially available formulations are the crude extract, silymarin, …
A systematic approach to evaluate herb-drug interaction mechanisms: investigation of milk thistle extracts and eight isolated constituents as CYP3A inhibitors
Despite increasing recognition of potential untoward interactions between herbal products
and conventional medications, a standard system for prospective assessment of these …
and conventional medications, a standard system for prospective assessment of these …
Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes
E Kim, A Sy-Cordero, TN Graf, SJ Brantley… - Planta …, 2011 - thieme-connect.com
Cranberry juice is used routinely, especially among women and the elderly, to prevent and
treat urinary tract infections. These individuals are likely to be taking medications …
treat urinary tract infections. These individuals are likely to be taking medications …
[HTML][HTML] Pharmacokinetics and comparative bioavailability of apomorphine sublingual film and subcutaneous apomorphine formulations in patients with Parkinson's …
F Agbo, SH Isaacson, R Gil, YY Chiu, SJ Brantley… - Neurology and …, 2021 - Springer
Introduction In a pivotal study, apomorphine sublingual film (APL; KYNMOBI ® ) was an
effective and generally well-tolerated on-demand treatment of “OFF” episodes in patients with …
effective and generally well-tolerated on-demand treatment of “OFF” episodes in patients with …
Enhanced bioactivity of silybin B methylation products
…, MC Wani, DJ Kroll, R Agarwal, SJ Brantley… - Bioorganic & medicinal …, 2013 - Elsevier
Flavonolignans from milk thistle (Silybum marianum) have been investigated for their cellular
modulatory properties, including cancer chemoprevention and hepatoprotection, as an …
modulatory properties, including cancer chemoprevention and hepatoprotection, as an …
The warfarin–cranberry juice interaction revisited: A systematic in vitro–in vivo evaluation
N Ngo, SJ Brantley, DR Carrizosa… - Journal of …, 2010 - Taylor & Francis
Background Cranberry products have been implicated in several case reports to enhance
the anticoagulant effect of warfarin. The mechanism could involve inhibition of the hepatic …
the anticoagulant effect of warfarin. The mechanism could involve inhibition of the hepatic …
Napabucasin Drug‐Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers
…, MT Goulet, CF McLaughlin, SJ Brantley - Clinical …, 2021 - Wiley Online Library
Napabucasin is an orally administered reactive oxygen species generator that is
bioactivated by the intracellular antioxidant nicotinamide adenine dinucleotide phosphate:quinone …
bioactivated by the intracellular antioxidant nicotinamide adenine dinucleotide phosphate:quinone …
Assessment of Azeliragon QTc Liability Through Integrated, Model‐Based Concentration QTc Analysis
AH Burstein, SJ Brantley, I Dunn… - Clinical …, 2019 - Wiley Online Library
Azeliragon is an inhibitor of the receptor for advanced glycation end products being developed
for the treatment of Alzheimer's disease. The objective of the current analysis was to …
for the treatment of Alzheimer's disease. The objective of the current analysis was to …
Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening
SJ Brantley, SW Cotten, DR Lamson, GR Smith… - Biochemical and …, 2017 - Elsevier
C. elegans has been widely used as a model organism for programmed cell death and
apoptosis. Although the CED-3 caspase is the primary effector of cell death in C. elegans, no …
apoptosis. Although the CED-3 caspase is the primary effector of cell death in C. elegans, no …