… Our results unveiled the existence of three NAFLD metabolic phenotypes: M subtype, non-M
subtype, and indeterminate subtype. All three metabolomic phenotypes were found in both …

Activation of the PTEN–PI3K–mTORC1 pathway consolidates metabolic programs that
sustain cancer cell growth and proliferation 1 , 2 . Here we show that mechanistic target of …

Nonalcoholic steatohepatitis (NASH) is the advanced form of nonalcoholic fatty liver disease
(NAFLD) that sets the stage for further liver damage. The mechanism for the progression of …

S-Adenosylmethionine (SAMe) is the principal methyl donor of the cell and is synthesized
via an ATP-driven process by methionine adenosyltransferase (MAT) enzymes. It is tightly …

Background Cholangiocarcinoma (CCA) is still a deadly tumour. Histological and molecular
aspects of thioacetamide (TAA)-induced intrahepatic CCA (iCCA) in rats mimic those of …

Here we present a high-resolution screening (HRS) methodology for postcolumn on-line
profiling of metabolites with affinity for the estrogen receptor α (ERα). Tamoxifen, which is …

Most plant species develop stress symptoms when exposed to high ammonium (NH 4 + )
concentrations. The root is the first organ in contact with high NH 4 + and therefore the first …

A high-resolution screening platform, coupling online affinity detection for mammalian
cytochrome P450s (Cyt P450s) to gradient reversed-phase high-performance liquid …

Reactive oxygen species (ROS) can damage proteins, cause lipid peroxidation, and react
with DNA, ultimately resulting in harmful effects. Antioxidants constitute one of the defense …

We present a fully automated and hyphenated bioanalytical method for metabolic profiling
of potentially harmful xenoestrogens. The system consists of an on-line cytochrome P450 …