In vitro assays using liver subcellular fractions or suspended hepatocytes for characterizing
the metabolism of drug candidates play an integral role in the optimization strategy …

The FDA issued a guidance on the safety testing of metabolites in February 2008, in which
they stated that metabolites of concern are those that are detected at levels greater than 10% …

Arctic climate change poses serious threats to polar bears (Ursus maritimus) as reduced
sea ice makes seal prey inaccessible and marine ecosystems undergo bottom‐up …

The late adoption of pottery technology in the North American Arctic between 2,500 and
2,800 years ago coincides with the development of a specialized maritime economy. Arctic …

Aldehydes are attractive chemical targets both as end products in the flavors and fragrances
industry and as synthetic intermediates due to their propensity for C–C bond formation. Here…

In recent years, sport psychology professionals (SPPs) have recognized the importance of
being aware of culture in their scholarly and applied practice. However, there is still a …

Beta-hydroxy non-standard amino acids (β-OH-nsAAs) have utility as small molecule drugs,
precursors for beta-lactone antibiotics, and building blocks for polypeptides. While the L-…

The increasing number of external threats from environmental and human-caused hazards
requires that emergency health care systems, including healthcare facilities, support services…

Helicobacter pylori is an important human pathogen with increasing antimicrobial resistance
to standard-of-care antibiotics. Treatment generally includes a combination of classical …

One of the major drawbacks for many biocatalysts is their poor stability under industrial
process conditions. A particularly interesting example is the supply of oxygen to biooxidation …