Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: selectivity, kinetic characterization, and molecular modeling
SN Lo, YP Chang, KC Tsai, CY Chang, TS Wu… - Toxicology and applied …, 2013 - Elsevier
Cytochrome P450 (P450, CYP) 1 family plays a primary role in the detoxification and bioactivation
of polycyclic aromatic hydrocarbons. Human CYP1A1, CYP1A2, and CYP1B1 exhibit …
of polycyclic aromatic hydrocarbons. Human CYP1A1, CYP1A2, and CYP1B1 exhibit …
[HTML][HTML] Berberine activates aryl hydrocarbon receptor but suppresses CYP1A1 induction through miR-21-3p stimulation in MCF-7 breast cancer cells
SN Lo, CW Wang, YS Chen, CC Huang, TS Wu, LA Li… - Molecules, 2017 - mdpi.com
Berberine and the methylenedioxy ring-opening derivatives palmatine and jatrorrhizine are
active ingredients in immunomodulatory plants, such as goldenseal. This study aimed to …
active ingredients in immunomodulatory plants, such as goldenseal. This study aimed to …
[HTML][HTML] Evaluation of Nanotargeted 111In-Cyclic RGDfK-Liposome in a Human Melanoma Xenotransplantation Model
SY Liu, SN Lo, WC Lee, WC Hsu, TW Lee… - International Journal of …, 2021 - mdpi.com
Nanotargeted liposomes may be modified with targeting peptide on the surface of a prepared
liposome to endow specificity and elevate targeting efficiency. The aim of this study was to …
liposome to endow specificity and elevate targeting efficiency. The aim of this study was to …
The effect of oxidation on berberine-mediated CYP1 inhibition: oxidation behavior and metabolite-mediated inhibition
SN Lo, CC Shen, CY Chang, KC Tsai, CC Huang… - Drug Metabolism and …, 2015 - ASPET
The protoberberine alkaloid berberine carries methylenedioxy moiety and exerts a variety of
pharmacological effects, such as anti-inflammation and lipid-lowering effects. Berberine …
pharmacological effects, such as anti-inflammation and lipid-lowering effects. Berberine …
[HTML][HTML] Antiinflammation Derived Suzuki-Coupled Fenbufens as COX-2 Inhibitors: Minilibrary Construction and Bioassay
SS Farn, YB Lai, KF Hua, HP Chen, TY Yu, SN Lo… - Molecules, 2022 - mdpi.com
A small fenbufen library comprising 18 compounds was prepared via Suzuki Miyara
coupling. The five-step preparations deliver 9–17% biphenyl compounds in total yield. These …
coupling. The five-step preparations deliver 9–17% biphenyl compounds in total yield. These …
[HTML][HTML] Bi-Functional Radiotheranostics of 188Re-Liposome-Fcy-hEGF for Radio- and Chemo-Therapy of EGFR-Overexpressing Cancer Cells
YS Huang, WC Hsu, CH Lin, SN Lo, CN Cheng… - International Journal of …, 2021 - mdpi.com
Epidermal growth factor receptor (EGFR) specific therapeutics is of great importance in
cancer treatment. Fcy-hEGF fusion protein, composed of yeast cytosine deaminase (Fcy) and …
cancer treatment. Fcy-hEGF fusion protein, composed of yeast cytosine deaminase (Fcy) and …
Molecular Imaging for Radiolabeling a PSMA-Targeted Long Circulating Peptide as a Theranostic Agent in Mice Bearing a Human Prostate Tumor
MH Li, SN Lo, MW Chen, WL Lo, YR Huang… - Journal of Medical and …, 2021 - Springer
Purpose 177 Lu-PSMA-617 is a promising radiotheranostic agent for metastatic castration-resistant
prostate cancer (mCRPC) patients that is composed of prostate-specific membrane …
prostate cancer (mCRPC) patients that is composed of prostate-specific membrane …
Imaging and biodistribution of radiolabeled SP90 peptide in BT-483 tumor bearing mice
WL Lo, CH Liang, LC Chen, SY Lee, SN Lo… - Applied Radiation and …, 2020 - Elsevier
The objective of this study was to evaluate radiolabeled DOTA-SP90 as a radiotracer for
breast cancer. The in vitro competition assay showed that radiolabeled DOTA-SP90 had …
breast cancer. The in vitro competition assay showed that radiolabeled DOTA-SP90 had …
[HTML][HTML] Effective Activation by Kynurenic Acid and Its Aminoalkylated Derivatives on M-Type K+ Current
YC Lo, CL Lin, WY Fang, B Lőrinczi, I Szatmári… - International journal of …, 2021 - mdpi.com
Kynurenic acid (KYNA, 4-oxoquinoline-2-carboxylic acid), an intermediate of the tryptophan
metabolism, has been recognized to exert different neuroactive actions; however, the need …
metabolism, has been recognized to exert different neuroactive actions; however, the need …
[HTML][HTML] The clinical significance and biological function of lncRNA RGMB-AS1 in hepatocellular carcinoma
N Sheng, Y Li, R Qian, Y Li - Biomedicine & Pharmacotherapy, 2018 - Elsevier
… Four hepatocellular carcinoma cell lines (QGY-7703, HuH7, BEL-7402 and HepG2) and a
normal hepatic cell line (LO-2) were purchased from the Cell Bank of Type Culture Collection …
normal hepatic cell line (LO-2) were purchased from the Cell Bank of Type Culture Collection …