Aberrant miRNA expression has been associated with many diseases, and extracellular
miRNAs that circulate in the bloodstream are remarkably stable. Recently, there has been …

Inhibition of hepatic transporters such as organic anion transporting polypeptides (OATPs)
1B can cause drug-drug interactions (DDIs). Determining the impact of perpetrator drugs on …

Mitogen-activated protein kinases (MAP kinases) are active only when phosphorylated. Here
we examine whether the activation of Xenopus p42 MAP kinase might involve changes in …

A method using Cedex automatic cell counter (Innovatis) to determine the cell density and
viability of a whole cell-based immunotherapy product has been developed and validated for …

Aim: Expression of PD-L1 in the tumor is associated with more favorable responses to anti-PD-1
therapy in multiple cancers. However, obtaining tumor biopsies for PD-L1 interrogation …

Objectives To assess the lipid-lowering efficacy of ezetimibe in dyslipidemic cynomolgus
monkeys comparing two dosing methods, and to evaluate PCSK9 plasma levels during …

Paramecium tetraurelia has thousands of secretory granules (trichocysts), which release
their protein contents by regulated exocytosis. The secretory proteins that fill the granule …

Adenoviral vectors have been widely used in gene therapy clinical trials and subjected to
rigorous testing to ensure safety and efficacy. Like therapeutic proteins, aggregation of …

Recent advances in the design of the scanning electron microscope (SEM) column, such as
the coupling of a field‐emission gun to a low‐aberration immersion lens and the availability …

We used polyclonal serum raised against mature trichocyst matrix proteins to detect their
unprocessed precursors, a group of proteins (45-55 kDa) present in the whole-cell extract. …