BACKGROUND: Ultra-filtration failure is a serious complication of long-term continuous
ambulatory peritoneal dialysis (CAPD). This complication is related to histological changes of the …

This report describes a potent and selective inhibitor of multidrug and toxin extrusion (MATE)
protein, pyrimethamine (PYR), and examines its effect on the urinary and biliary excretion …

Vascular changes in the peritoneum were histochemically assessed in patients on continuous
ambulatory peritoneal dialysis (CAPD) with ultrafiltration failure. Light microscopy showed …

Simultaneous use of nonsteroidal anti-inflammatory drugs (NSAIDs), probenecid, and other
drugs has been reported to delay the plasma elimination of methotrexate in patients. …

Recent linkage analyses of nondiabetic African-American patients with focal segmental
glomerulosclerosis (FSGS) have identified MYH9, encoding nonmuscle myosin heavy chain IIA (…

Probe substrates for, and inhibitors of, specific transporters are desired to evaluate quantitatively
the in vivo functions of transporters in humans. Based on published data, adefovir and …

The present study investigated prediction of the overall renal tubular secretion and hepatic
clearances of anionic drugs based on in vitro transport studies. The saturable uptake of eight …

Cimetidine is known to cause drug-drug interactions (DDIs) with organic cations in the kidney,
and a previous clinical study showed that coadministration of cimetidine or probenecid …

The purpose of this study was to assess the effect of a low‐dose rituximab (RIT) at <375 mg/m
2 on B cells in the spleen and peripheral blood. Five renal transplant recipients received a …

PURPOSE:: The presence and potential role of chemokines in clinical tumors remain poorly
understood. Chemokines are a large family of chemoattractant cytokines with several …