[PDF][PDF] New aspects of cadmium as endocrine disruptor

M Takiguchi, S Yoshihara - Environ Sci, 2006 - scholar.archive.org
Cadmium (Cd) is an industrial and environmental pollutant that exerts adverse effects on a
number of organs in humans and animals. Reproductive organs, such as the testis and …

Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds

…, N Jinno, K Sugihara, S Yoshihara… - Toxicological …, 2005 - academic.oup.com
The endocrine-disrupting activities of bisphenol A (BPA) and 19 related compounds were
comparatively examined by means of different in vitro and in vivo reporter assays. BPA and …

Potent estrogenic metabolites of bisphenol A and bisphenol B formed by rat liver S9 fraction: their structures and estrogenic potency

S Yoshihara, T Mizutare, M Makishima… - Toxicological …, 2004 - academic.oup.com
We previously demonstrated that the estrogenicity of either bisphenol A [BPA; 2,2-bis(4-hydroxyphenyl)propane]
or bisphenol B [BPB; 2,2-bis(4-hydroxyphenyl)butane] was increased …

Metabolic activation of bisphenol A by rat liver S9 fraction

S Yoshihara, M Makishima, N Suzuki… - Toxicological …, 2001 - academic.oup.com
Bisphenol A (BPA) is a well-known endocrine-disrupting chemical found in the environment.
To assess the metabolic modulation of estrogenic activity of BPA after ingestion, we …

Novel pathway of metabolic activation of bisphenol A-related compounds for estrogenic activity

…, T Fukuuchi, M Takiguchi, S Yoshihara - Drug metabolism and …, 2011 - ASPET
We previously demonstrated that estrogenic activity of bisphenol A (BPA) in the yeast estrogen
screening assay was increased severalfold after incubation with rat liver S9 fraction in the …

In vivo estrogenic potential of 4-methyl-2, 4-bis (4-hydroxyphenyl) pent-1-ene, an active metabolite of bisphenol A, in uterus of ovariectomized rat

K Okuda, M Takiguchi, S Yoshihara - Toxicology letters, 2010 - Elsevier
4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), an active metabolite of bisphenol A (BPA),
has more potent estrogenic activity than BPA in vitro, but its activity in vivo is not …

Toxicity to early life stages and an estrogenic effect of a bisphenol A metabolite, 4-methyl-2, 4-bis (4-hydroxyphenyl) pent-1-ene on the medaka (Oryzias latipes)

…, Y Nagao, H Shiratsuchi, S Kohra, S Yoshihara… - Life sciences, 2005 - Elsevier
In a recent study, it was reported that 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP),
a metabolite of bisphenol A (BPA; 2,2-bis(4-hydroxyphenyl)propane), showed estrogenic …

Bisphenol A modulates the metabolic regulator oestrogenrelated receptor-a in T-cells

R Cipelli, L Harries, K Okuda, S Yoshihara… - …, 2014 - rep.bioscientifica.com
Bisphenol A (BPA) is a widely used plastics constituent that has been associated with
endocrine, immune and metabolic effects. Evidence for how BPA exerts significant biological …

Repeated exposure to 4-methyl-2, 4-bis (4-hydroxyphenyl) pent-1-ene (MBP), an active metabolite of bisphenol A, aggressively stimulates breast cancer cell growth in …

…, S Takeda, K Okuda, M Takiguchi, S Yoshihara - Molecular …, 2019 - ASPET
Bisphenol A (BPA), recognized as an endocrine disruptor, is thought to exert its activity through
a mechanism involving the activation of estrogen receptors (ERs) α/β. However, a major …

Possible correlation between induction modes of hepatic enzymes by PCBs and their toxicity in rats.

H Yoshimura, S Yoshihara, N Ozawa… - Annals of the New York …, 1979 - europepmc.org
Acute toxicity of individual PCBs, which were categorized as either phenobarbital (PB)-or 3-methylcholanthrene
(MC)-type inducers, was examined in young male Wistar rats, …