Several novel UDP glycosyltransferase (UGT) genes, mainly UDP glucuronosyltransferases,
have been identified in the human, mouse and rat genomes and in other mammalian …

Bilirubin, the oxidative product of heme in mammals, is excreted into the bile after its esterification
with glucuronic acid to polar mono- and diconjugated derivatives. The accumulation of …

UDP-glucuronosyltransferases (UGTs) catalyze glucuronidation of a variety of xenobiotics
and endobiotics. UGTs are divided into two families, UGT1 and UGT2. The purpose of this …

Bisphenol A, an environmental oestrogenic chemical, was found to conjugate highly with
glucuronic acid in male rat liver microsomes studied in vitro. In the various isoforms tested (1A1…

Polychlorinated dibenzo-p-dioxins (PCDDs) and coplanar polychlorinated biphenyls (PCBs)
contribute to dioxin toxicity in humans and wildlife after bioaccumulation through the food …

Vitamin D 3 (VD 3 ), a prohormone in mammals, plays a crucial role in the maintenance of
calcium and phosphorus concentrations in serum. Activation of VD 3 requires 25-…

The glucuronidation of 17β-estradiol (β-estradiol) and 17α-estradiol (epiestradiol) was studied
to elucidate how the orientation of the 17-OH group affects conjugation at the 3-OH or the …

Rats that consumed a high-fat and high-sucrose (HF1) diet or a high-fat (HF2) diet developed
hepatic steatosis. The alteration in nutritional status affected hepatic cytochrome P450 and …

The interactions between UDP-glucuronosyltransferase (UGT) isozymes, UGT1s and UGT2B1,
in rat hepatic microsomes were investigated using an immunopurification technique with …

Genomic clones of UDP-glucuronosyltransferase family 1 (UGT1) were isolated from wild-type
Wistar rats. The UGT1 locus spans > 120 kb and forms a gene complex. In this locus nine …