Cytochrome P450 (CYP) 2A6 catalyzes nicotine C‐oxidation, leading to cotinine formation,
a major metabolic pathway of nicotine in humans. There are genetic polymorphisms in the …

Natto, steamed soybeans fermented by Bacillus subtilis natto, is a traditional Japanese food.
We derived a purified protein layer, called NKCP as a trade mark, from B. subtilis natto …

Object. The authors have attempted to define the exact borders of the root exit zone (RExZ)
of the facial nerve, measure the distribution of myelin histologically, and examine the …

Capecitabine, a prodrug of 5-fluorouracil, is first metabolized to 5′-deoxy-5-fluorocytidine (5′-DFCR)
by carboxylesterase (CES), which is mainly expressed in microsomes. Recently, …

Indomethacin is a widely used nonsteroidal anti-inflammatory drug. We studied the human
cytochrome P450 (CYP) isoform responsible for indomethacin O-demethylation, the major …

We present a practical case in which the fungi have contributed to the estimation of postmortem
interval of the cadaver. A 71-year-old man wearing a shirt and pants was found dead at …

We examined and identified fungi flora found growing on two human cadavers. The main
isolate colonized on the surfaces of the skin and bones was morphologically identified as …

Azelastine, an antiallergy and antiasthmatic drug, has been reported to be mainly N-demethylated
to desmethylazelastine in humans. In the present study, Eadie-Hofstee plots of …

OBJECTIVE: The aim of this study was to understand the injury mechanisms of pregnant
drivers and associated fetal outcomes. STUDY DESIGN: Frontal and rear impact tests using a …

Capecitabine, an anticancer prodrug, is thought to be biotransformed into active 5-fluorouracil
(5-FU) by three enzymes. After oral administration, capecitabine is first metabolized to 5′-…