NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.

…, K Yoshikawa, Y Hamasaka, I Arai, S Higuchi… - General …, 1993 - europepmc.org
1. NS-398 (N-[2-cyclohexyloxy-4-nitrophenyl] methanesulfonamide) is a new non-steroidal
anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. 2. The anti-…

Gastric pH profiles of beagle dogs and their use as an alternative to human testing

…, N Nagahata, A Furuya, K Fukushima, S Higuchi… - European Journal of …, 2000 - Elsevier
Gastric pH levels were measured in samples of gastric aspirates from eight fasted beagle
dogs. The gastric pH in fasting dogs fluctuated from 2.7 to 8.3, with a mean of 6.8±0.2 (SE). …

Liver metastases: correlation between imaging features and pathomolecular environments

K Ozaki, S Higuchi, H Kimura, T Gabata - Radiographics, 2022 - pubs.rsna.org
A wide range of imaging manifestations of liver metastases can be encountered, as various
primary cancers preferably metastasize to the liver (organ-specific metastases), with the …

[HTML][HTML] Exploration of sepsis assisting parameters in hospital autopsied-patients: A prospective study

K Inai, S Higuchi, A Shimada, K Hisada, Y Hida… - Scientific Reports, 2023 - nature.com
Although Sepsis-3 doesn’t require evidence of bacteremia to diagnose sepsis, clinicians
often want to identify the causative pathogen at autopsy. In principle, if the blood cultures are …

Pearls and pitfalls of imaging features of pancreatic cystic lesions: a case-based approach with imaging–pathologic correlation

K Ozaki, H Ikeno, Y Kaizaki, K Maeda, S Higuchi… - Japanese Journal of …, 2021 - Springer
A variety of neoplastic and non-neoplastic lesions of the pancreas can present with a
predominantly cystic architecture. These lesions are increasingly being detected as incidental …

Exciton diffusion in -encapsulated monolayer

T Hotta, S Higuchi, A Ueda, K Shinokita, Y Miyauchi… - Physical Review B, 2020 - APS
Excitons, quasiparticles composed of an electron and a hole, play an important role in optical
responses in low-dimensional nanostructures. In this work, we have investigated exciton …

Lysosomal cysteine and aspartic proteinases, acid phosphatase, and an endogenous cysteine proteinase inhibitor, cystatin-beta, in rat osteoclasts.

Y Ohsawa, T Nitatori, S Higuchi… - … of Histochemistry & …, 1993 - journals.sagepub.com
To understand the bone resorption and lysosomal proteinases in osteoclasts, we examined
by immunohistochemistry the localization of lysosomal cysteine and aspartic proteinases, …

Enhanced Exciton–Exciton Collisions in an Ultraflat Monolayer MoSe2 Prepared through Deterministic Flattening

T Hotta, A Ueda, S Higuchi, M Okada, T Shimizu… - Acs Nano, 2020 - ACS Publications
Squeezing bubbles and impurities out of interlayer spaces by applying force through a few-layer
graphene capping layer leads to van der Waals heterostructures with the ultraflat …

Determination of pibutidine metabolites in human plasma by LC-MS/MS

K Kato, S Jingu, N Ogawa, S Higuchi - Journal of pharmaceutical and …, 2000 - Elsevier
A novel metabolite-screening procedure for pibutidine, an H 2 -receptor antagonist, which
uses high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS), …

CYP isoforms involved in the metabolism of clarithromycin in vitro: comparison between the identification from disappearance rate and that from formation rate of …

A Suzuki, I Iida, M Hirota, M Akimoto, S Higuchi… - Drug metabolism and …, 2003 - Elsevier
To clarify whether CYP2C19 is involved in the overall metabolism of clarithromycin (CAM) or
not, in vitro studies using human liver microsomes and recombinant CYPs were performed …