User profiles for Shoko Kobayashi

Shoko Kobayashi

The University of Tokyo
Verified email at g.ecc.u-tokyo.ac.jp
Cited by 1985

Transepithelial transport of chlorogenic acid, caffeic acid, and their colonic metabolites in intestinal Caco-2 cell monolayers

Y Konishi, S Kobayashi - Journal of agricultural and food …, 2004 - ACS Publications
Both chlorogenic and caffeic acids exhibited nonsaturable transport in Caco-2 cells,
whereas caffeic acid also showed proton-coupled polarized absorption. Thus, the absorption …

Interleukin-11 enhances human megakaryocytopoiesis in vitro

M Teramura, S Kobayashi, S Hoshino, K Oshimi… - 1992 - ashpublications.org
We investigated the effect of recombinant human interleukin-11 (rhIL- 11) on human
megakaryocytopoiesis. Nonadherent and T-cell-depleted human bone marrow (BM) mononuclear …

Transepithelial transport of p-coumaric acid and gallic acid in Caco-2 cell monolayers

Y Konishi, S Kobayashi, M Shimizu - Bioscience, biotechnology, and …, 2003 - jstage.jst.go.jp
The transepithelial transport of such common dietary phenolic acids as p-coumaric acid (CA)
and gallic acid (GA) across Caco-2 cell monolayers was examined. CA transport was …

[HTML][HTML] Rosmarinic acid suppresses Alzheimer's disease development by reducing amyloid β aggregation by increasing monoamine secretion

…, M Noguchi-Shinohara, M Yamada, S Kobayashi - Scientific Reports, 2019 - nature.com
A new mechanism is revealed by which a polyphenol, rosmarinic acid (RA), suppresses
amyloid β (Aβ) accumulation in mice. Here we examined the brains of mice (Alzheimer’s …

[HTML][HTML] Luteolin and quercetin affect the cholesterol absorption mediated by epithelial cholesterol transporter Niemann–Pick C1-Like 1 in caco-2 cells and rats

…, K Nakazawa, H Kato, T Misaka, K Abe, S Kobayashi - PloS one, 2014 - journals.plos.org
Niemann–Pick C1-Like 1 (NPC1L1) mediates cholesterol absorption, and ezetimibe is a
potent NPC1L1 inhibitor applicable for medication of hypercholesterolemia. Epidemiological …

[HTML][HTML] Pharmacokinetics, Safety and Tolerability of Melissa officinalis Extract which Contained Rosmarinic Acid in Healthy Individuals: A Randomized Controlled …

…, K Ono, T Hamaguchi, K Iwasa, T Nagai, S Kobayashi… - PloS one, 2015 - journals.plos.org
The aim of this study was to evaluate the safety, tolerability and pharmacokinetics of single
dose of Melissa officinalis extract which contained rosmarinic acid, including food-effects in …

Transepithelial transport of rosmarinic acid in intestinal Caco-2 cell monolayers

Y Konishi, S Kobayashi - Bioscience, biotechnology, and …, 2005 - jstage.jst.go.jp
The absorption characteristics of rosmarinic acid (RA) were examined by measuring permeation
across Caco-2 cell monolayers using an HPLC-electrochemical detector (ECD) fitted …

Embryonic and fetal β‐globin gene repression by the orphan nuclear receptors, TR2 and TR4

O Tanabe, D McPhee, S Kobayashi, Y Shen… - The EMBO …, 2007 - embopress.org
The TR2 and TR4 orphan nuclear receptors comprise the DNA‐binding core of direct repeat
erythroid definitive, a protein complex that binds to direct repeat elements in the embryonic …

[HTML][HTML] Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer's disease progression

…, K Ono, T Hamaguchi, T Nagai, S Kobayashi… - Scientific reports, 2020 - nature.com
We conducted a randomized placebo-controlled double-blind 24-week trial using Melissa
officinalis (M. officinalis) extract richly containing rosmarinic acid (RA) on patients with mild …

[HTML][HTML] Transepithelial transport of hesperetin and hesperidin in intestinal Caco-2 cell monolayers

S Kobayashi, S Tanabe, M Sugiyama… - Biochimica et Biophysica …, 2008 - Elsevier
The cell permeability of hesperetin and hesperidin, anti-allergic compounds from citrus fruits,
was measured using Caco-2 monolayers. In the presence of a proton gradient, hesperetin …