Liver biology and function, drug-induced liver injury (DILI) and liver diseases are difficult to
study using current in vitro models such as primary human hepatocyte (PHH) monolayer …

Background Variability in genes implicated in drug pharmacokinetics or drug response can
modulate treatment efficacy or predispose to adverse drug reactions. Besides common …

Membrane penetration of nonenveloped viruses is a poorly understood process. We have
investigated early stages of this process by studying the conformational change experienced …

Prediction of phenotypic consequences of mutations constitutes an important aspect of
precision medicine. Current computational tools mostly rely on evolutionary conservation and …

Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing differentiated
and dedifferentiated proliferating states in vivo. However, in two‐dimensional cultures, …

Background In contrast to general anesthetics such as propofol, dexmedetomidine when used
for sedation has been put forward as a drug with minimal effects on respiration. To obtain …

Folding and post-translational modification of the thyroid hormone precursor, thyroglobulin (Tg),
in the endoplasmic reticulum (ER) of the thyroid epithelial cells is facilitated by several …

Cytochrome P450 2W1 (CYP2W1) is expressed at high levels in colorectal cancer cells.
Moreover, we have shown previously that a higher tumor expression is associated with less …

The liver fulfills central roles in metabolic control and detoxification and, as such, is continuously
exposed to a plethora of insults. Importantly, the liver has a unique ability to regenerate …

We have investigated mechanisms of omeprazole (OME)-mediated induction of CYP1A1 and
CYP3A, using the rat hepatoma H4IIE cell line, in comparison with mechanisms exerted by …