A stereospecific high‐performance liquid chromatographic (HPLC) method was developed
for the quantitation of the enantiomers of venlafaxine, an antidepressant, in dog, rat, and …

Retinoids are compounds that bind to and activate one or more retinoid receptors to elicit
various physiological responses. There are two families of retinoid receptors, ie retinoic acid …

The metabolism of bexarotene, a rexinoid recently approved in the United States for treatment
of cutaneous T-cell lymphoma, was studied using liver slices from untreated rats and dogs…

We demonstrate here that RNA levels of 25-hydroxyvitamin D 3 -24-hydroxylase (24-(OH)ase),
a key catabolic enzyme for 1,25-dihydroxyvitamin D 3 , are increased by a highly …

LGD1069 (Targretin), a retinoid “X” receptor-selective ligand, or rexinoid, is in clinical trials
for treating cancer. Biologically-active oxidized LGD1069 metabolites have been observed in …

The pharmacokinetics, metabolism, and excretion of ciclesonide, a novel and effective inhaled
glucocorticoid for the treatment of asthma, were investigated after intravenous and oral …

A circadian cycle in hepatic UDP-glucuronic acid (UDP-GA) concentration was observed in
mice that was essentially the reverse of those seen for hepatic glycogen and UDP-glucose. …

The in vitro metabolism of ciclesonide, a novel inhaled nonhalogenated glucocorticoid for the
treatment of asthma, was compared in cryopreserved hepatocytes from mice, rats, rabbits, …

The hepatotoxic properties of concurrent chronic oral ethanol ingestion and acute toluene
inhalation were evaluated. Male rats were maintained on ethanol-containing or control liquid …

Salicylamide is an important model compound for use in investigations concerning drug
disposition. In this study the metabolic fate of salicylamide at high doses was evaluated in male …