Current regulatory guidances do not address specific study designs for in vitro and in vivo
drug-drug interaction studies. There is a common desire by regulatory authorities and by …

Current regulatory guidances do not address specific study designs for in vitro and in vivo
drug‐drug interaction studies. There is a common desire by regulatory authorities and by …

This is an introductory text intended to give the newcomer to this area a comprehensive insight
into the science of biotransformations. The book traces the history of biotransformations, …

Poly-L-leucine catalyses the asymmetric epoxidation of enones 1–6 efficiently in a non-aqueous
medium to provide the epoxy ketones 7–12 (70–91% yield; 80 to 95% ee). The strategy …

This volume is designed for chemists working in an organic chemistry laboratory and for all
scientists with an interest in biotransformations. It summarizes the important aspects of work …

Purpose. The objective of this study was to examine the metabolism and disposition of the
HIV protease inhibitor lopinavir in humans and animal models. Methods. The plasma protein …

The report from the 2002 International Workshop on Genotoxicity Tests (IWGT) Strategy
Expert Group emphasized metabolic considerations as an important area to address in …

For the resolution of the bicyclic lactam 2-azabicyclo[2.2.1]hept-5-en-3-one, efficient whole
cell biocatalysts have been identified and from these, enzymes (lactamases) have been …

Preparative-scale biotransformations of cyclic and bicyclic ketones yielding optically active
lactones are illustrated. The use of whole cell systems such as Acinetobacter calcoaceticus to …

… Roberts, John Whittall. Ferrocene-based aminophosphine ligands in the Ru(II)-catalysed
asymmetric hydrogenation of ketones: assessment of the relative importance of planar versus …