Any psychological merit which this paper may possess is due entirely to the teaching and
inspiration of Professor James R. Angell under whom I have worked. I am glad also here to …

The metabolism and excretion of [ 14 C]sitagliptin, an orally active, potent and selective
dipeptidyl peptidase 4 inhibitor, were investigated in humans after a single oral dose of 83 mg/…

A potent, selective glucagon receptor antagonist 9m, N-[(4-{(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine,
was …

The pharmacokinetics, metabolism, and excretion of sitagliptin [MK-0431; (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan…

The voltage-gated potassium channel, Kv1.3, is specifically expressed on human lymphocytes,
where it controls membrane potential and calcium influx. Blockade of Kv1.3 channels by …

Midazolam is a potent benzodiazepine derivative with sedative, hypnotic, anticonvulsant,
muscle-relaxant, and anxiolytic activities. It undergoes oxidative metabolism catalyzed almost …

3,3-Disubstituted oxetanes have been utilized as bioisosteres for gem-dimethyl and cyclobutane
functionalities. We report the discovery of a novel class of oxetane indole-amine 2,3-…

… Stella Vincent Stella Vincent … More by Stella Vincent …

Stereospecific introduction of a methyl group to the indole-3-side chain enhanced activity in
our tryptamine-derived series of GnRH receptor antagonists. Further improvements were …

Directed screening of a carboxylic acid-containing combinatorial library led to the discovery
of potent inhibitors of the integrin VLA-4. Subsequent optimization by solid-phase synthesis …