Model‐Informed Therapeutic Dose Optimization Strategies for Antibody–Drug Conjugates in Oncology: What Can We Learn From US Food and Drug Administration …
…, D Miles, D Samineni, SN Liu… - Clinical …, 2021 - Wiley Online Library
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the cytotoxicity
of a chemical agent. They represent a rapidly evolving area of oncology drug development …
of a chemical agent. They represent a rapidly evolving area of oncology drug development …
Clinical pharmacology perspectives for adoptive cell therapies in oncology
Adoptive cell therapies (ACTs) have shown transformative efficacy in oncology with five US
Food and Drug Administration (FDA) approvals for chimeric antigen receptor (CAR) T‐cell …
Food and Drug Administration (FDA) approvals for chimeric antigen receptor (CAR) T‐cell …
[HTML][HTML] Clinical pharmacology strategies in supporting drug development and approval of antibody–drug conjugates in oncology
SN Liu, C Li - Cancer Chemotherapy and Pharmacology, 2021 - Springer
Antibody–drug conjugates (ADCs) are important molecular entities in the treatment of cancer.
These conjugates combine the target specificity of monoclonal antibodies with the potent …
These conjugates combine the target specificity of monoclonal antibodies with the potent …
Mechanistic assessment of extrahepatic contributions to glucuronidation of integrase strand transfer inhibitors
SN Liu, JBL Lu, CJW Watson, P Lazarus, Z Desta… - Drug Metabolism and …, 2019 - ASPET
Integrase strand transfer inhibitor (INSTI)–based regimens dominate initial human
immunodeficiency virus treatment. Most INSTIs are metabolized predominantly via UDP-…
immunodeficiency virus treatment. Most INSTIs are metabolized predominantly via UDP-…
Probenecid‐boosted tenofovir: A physiologically‐based pharmacokinetic model‐informed strategy for on‐demand HIV preexposure prophylaxis
SN Liu, Z Desta, BT Gufford - CPT: Pharmacometrics & Systems …, 2020 - Wiley Online Library
Multiple doses of tenofovir disoproxil fumarate (TDF) together with emtricitabine is effective
for HIV preexposure prophylaxis (PrEP). TDF is converted to tenofovir (TFV) in circulation, …
for HIV preexposure prophylaxis (PrEP). TDF is converted to tenofovir (TFV) in circulation, …
Inhibitory Effects of Probenecid on Pharmacokinetics of Tenofovir Disoproxil Fumarate and Emtricitabine for On‐Demand HIV Preexposure Prophylaxis
SN Liu, BT Gufford, JBL Lu… - Clinical …, 2020 - Wiley Online Library
In a randomized, crossover pharmacokinetic study in healthy volunteers (N = 14), a single
dose of 2 g probenecid (PRO)‐boosted 600 mg tenofovir disoproxil fumarate (TDF)/400 mg …
dose of 2 g probenecid (PRO)‐boosted 600 mg tenofovir disoproxil fumarate (TDF)/400 mg …
Impact of dose delays and alternative dosing regimens on Pertuzumab pharmacokinetics
PERJETA (pertuzumab), administered with Herceptin (trastuzumab), is used in the treatment
of human epidermal growth factor receptor 2‐positive breast cancer. Pertuzumab is …
of human epidermal growth factor receptor 2‐positive breast cancer. Pertuzumab is …
Charge-balanced electrical stimulation can modulate neural precursor cell migration in the presence of endogenous electric fields in mouse brains
SN Iwasa, A Rashidi, E Sefton, NX Liu, MR Popovic… - eneuro, 2019 - eneuro.org
Electric fields (EFs) can direct cell migration and are crucial during development and tissue
repair. We previously reported neural precursor cells (NPCs) are electrosensitive cells that …
repair. We previously reported neural precursor cells (NPCs) are electrosensitive cells that …
[HTML][HTML] Risk factors for a severe form of COVID‐19 after allogeneic haematopoietic stem cell transplantation: a Société Francophone de Greffe de Moelle et de …
…, JO Bay, M Robin, S N'Guyen‐Quoc… - British journal of …, 2021 - ncbi.nlm.nih.gov
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), emerged in China in December 2019 and rapidly spread worldwide…
coronavirus-2 (SARS-CoV-2), emerged in China in December 2019 and rapidly spread worldwide…
[HTML][HTML] Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers
Packed with biological information, extracellular vesicles (EVs) offer exciting promise for
biomarker discovery and applications in therapeutics and non-invasive diagnostics. Currently, …
biomarker discovery and applications in therapeutics and non-invasive diagnostics. Currently, …