LWIR/MWIR imaging hyperspectral sensor for airborne and ground-based remote sensing

…, DW Warren, RP Bongiovi, SJ Hansel… - Imaging …, 1996 - spiedigitallibrary.org
We describe the design and performance of an infrared imaging spectrograph that was first
used as an airborne sensor in October, 1995. This instrument, called the spatially-enhanced …

Dynamics of β-amyloid reductions in brain, cerebrospinal fluid, and plasma of β-amyloid precursor protein transgenic mice treated with a γ-secretase inhibitor

DM Barten, VL Guss, JA Corsa, A Loo, SB Hansel… - … of Pharmacology and …, 2005 - ASPET
γ-Secretase inhibitors are one promising approach to the development of a therapeutic for
Alzheimer's disease (AD). γ-Secretase inhibitors reduce brain β-amyloid peptide (Aβ), which …

Discovery of a 1H-Benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity

…, M Gottardis, A Greer, S Hansel… - Journal of medicinal …, 2005 - ACS Publications
Steven HanselSteven Hansel - Discovery Chemistry, Department of Metabolism and
Pharmacokinetics, Department of Computer Aided Drug Design, and Department of Chemical …

Trends in industrialization of biotherapeutics: a survey of product characteristics of 89 antibody-based biotherapeutics

KP Martin, C Grimaldi, R Grempler, S Hansel, S Kumar - MAbs, 2023 - Taylor & Francis
There is considerable interest in the pharmaceutical industry toward development of
antibody-based biotherapeutics because they can selectively bind diverse receptors and often …

Where did the linker-payload go? A quantitative investigation on the destination of the released linker-payload from an antibody-drug conjugate with a maleimide …

…, F Barletta, LN Tumey, B Rago, S Hansel… - Analytical …, 2016 - ACS Publications
The reactive thiol of cysteine is often used for coupling maleimide-containing linker-payloads
to antibodies resulting in the generation of antibody drug conjugates (ADCs). Currently, a …

LC–MS/MS method development and validation for the determination of polymyxins and vancomycin in rat plasma

…, D Xiao, J Hollembaek, L Yao, J Lin, S Hansel - … of Chromatography B, 2010 - Elsevier
Simple, sensitive and robust liquid chromatography–tandem mass spectrometer (LC–MS/MS)
methods were developed and validated for the determination of lipopeptide polymyxins …

Immune-mediated agranulocytosis caused by the cocaine adulterant levamisole: a case for reactive metabolite (s) involvement

A Wolford, TS McDonald, H Eng, S Hansel… - Drug Metabolism and …, 2012 - ASPET
The United States Public Health Service Administration is alerting medical professionals
that a substantial percentage of cocaine imported into the United States is adulterated with …

Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents

…, YF Gong, MR Browning, Q Gao, S Hansel… - Bioorganic & medicinal …, 2013 - Elsevier
A series of substituted carboxamides at the indole C7 position of the previously described 4-fluoro-substituted
indole HIV-1 attachment inhibitor 1 was synthesized and the SAR …

An efficient method for the synthesis of guanidino prodrugs

…, DB Frennesson, MS Deshpande, SB Hansel… - Bioorganic & Medicinal …, 1994 - Elsevier
A new class of guanidino prodrug is efficiently synthesized from an amine and an
appropriate N,N′-bis(acyloxymethoxycarbonyl)-S-methylisothiourea. The N,N′-bis(…

Inhibitors of HIV-1 attachment. Part 8: the effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors

…, TP Spicer, YF Gong, MR Browning, S Hansel… - Bioorganic & medicinal …, 2013 - Elsevier
As part of the SAR profiling of the indole-oxoacetic piperazinyl benzamide class of HIV-1
attachment inhibitors, substitution at the C7 position of the lead 4-fluoroindole 2 with various 5- …