In-datacenter performance analysis of a tensor processing unit
…, D Killebrew, A Koch, N Kumar, S Lacy… - Proceedings of the 44th …, 2017 - dl.acm.org
Many architects believe that major improvements in cost-energy-performance must now
come from domain-specific hardware. This paper evaluates a custom ASIC---called a Tensor …
come from domain-specific hardware. This paper evaluates a custom ASIC---called a Tensor …
Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection
…, KJ Jakeman, J Merson, SA Lacy… - Antimicrobial agents …, 1998 - Am Soc Microbiol
We have recently described GS 4071, a carbocyclic transition-state analog inhibitor of the
influenza virus neuraminidase, which has potent inhibitory activity comparable to that of 4-…
influenza virus neuraminidase, which has potent inhibitory activity comparable to that of 4-…
Clinical pharmacokinetics and pharmacodynamics of cabozantinib
SA Lacy, DR Miles, LT Nguyen - Clinical pharmacokinetics, 2017 - Springer
Cabozantinib inhibits receptor tyrosine kinases involved in tumor angiogenesis and
metastasis. The capsule formulation (Cometriq ® ) is approved for the treatment of progressive …
metastasis. The capsule formulation (Cometriq ® ) is approved for the treatment of progressive …
Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys
SA Lacy, MJM Hitchcock, WA Lee, P Tellier… - Toxicological …, 1998 - academic.oup.com
In animals and humans, intravenous administration of the antiviral nucleotide analogue
cidofovir results in a dose-limiting nephrotoxicity characterized by damage to the proximal …
cidofovir results in a dose-limiting nephrotoxicity characterized by damage to the proximal …
Metabolism and disposition of cabozantinib in healthy male volunteers and pharmacologic characterization of its major metabolites
S Lacy, B Hsu, D Miles, D Aftab, R Wang… - Drug Metabolism and …, 2015 - ASPET
Metabolism and excretion of cabozantinib, an oral inhibitor of receptor tyrosine kinases, was
studied in 8 healthy male volunteers after a single oral dose of 175 mg cabozantinib l-…
studied in 8 healthy male volunteers after a single oral dose of 175 mg cabozantinib l-…
Pharmacokinetic (PK) drug interaction studies of cabozantinib: Effect of CYP3A inducer rifampin and inhibitor ketoconazole on cabozantinib plasma PK and effect of …
…, N Benrimoh, T O'Reilly, S Lacy - The Journal of …, 2015 - Wiley Online Library
Cabozantinib is a small‐molecule tyrosine kinase inhibitor that has been approved for the
treatment of patients with progressive, metastatic medullary thyroid cancer. In vitro data …
treatment of patients with progressive, metastatic medullary thyroid cancer. In vitro data …
Evaluation of the effect of food and gastric pH on the single‐dose pharmacokinetics of cabozantinib in healthy adult subjects
…, D Swearingen, D Armas, S Lacy - The Journal of …, 2015 - Wiley Online Library
Cabozantinib is a small molecule tyrosine kinase inhibitor that has been approved for the
treatment of patients with progressive, metastatic medullary thyroid cancer. Cabozantinib …
treatment of patients with progressive, metastatic medullary thyroid cancer. Cabozantinib …
[HTML][HTML] Population exposure–response analysis of cabozantinib efficacy and safety endpoints in patients with renal cell carcinoma
S Lacy, J Nielsen, B Yang, D Miles, L Nguyen… - Cancer Chemotherapy …, 2018 - Springer
… Steven Lacy and Linh Nguyen are stockholders and current employees of Exelixis, Inc.
Dale Miles was an employee of Exelixis, Inc. when this work was performed and is currently …
Dale Miles was an employee of Exelixis, Inc. when this work was performed and is currently …
[BOOK][B] Steve Lacy: Conversations
J Weiss - 2006 - books.google.com
… "As far back as I can remember, Steve Lacy has represented … "Steve Lacy's soul-rending
sounds emerge out of the chaos … "Steve Lacy was a universalist whose unending curiosity took …
sounds emerge out of the chaos … "Steve Lacy was a universalist whose unending curiosity took …
Effect of renal and hepatic impairment on the pharmacokinetics of cabozantinib
…, DM Heuman, E Gavis, S Lacy - The Journal of …, 2016 - Wiley Online Library
Cabozantinib is a tyrosine kinase inhibitor approved for the treatment of patients with
progressive, metastatic medullary thyroid cancer. Two clinical pharmacology studies were …
progressive, metastatic medullary thyroid cancer. Two clinical pharmacology studies were …