Methadone maintenance programs are considered the standard of care for the pregnant
opiate addict. However, data on changes in methadone pharmacokinetics (PK) during …

The receptor tyrosine kinase c-Met is an attractive target for therapeutic blockade in cancer.
Here, we describe MK-2461, a novel ATP-competitive multitargeted inhibitor of activated c-…

Methadone pharmacotherapy is considered the standard for treatment of the pregnant
heroin/opioid addict. One of the factors affecting the transfer kinetics of opioids across human …

c-Met is a transmembrane tyrosine kinase that mediates activation of several signaling
pathways implicated in aggressive cancer phenotypes. In recent years, research into this area …

This communication highlights the development of a nicotinamide series of histone
deacetylase inhibitors within the benzamide structural class. Extensive exploration around the …

Buprenorphine (BUP) is a partial opiate agonist used for treatment of the adult and the pregnant
addicted to this class of narcotics. The kinetic parameters for transplacental transfer and …

Histone deacetylase (HDAC) inhibitors that target Class I and Class II HDACs are of synthetic
and therapeutic interest and ongoing clinical studies indicate that they show great promise …

Synthesis and SAR studies of novel triazolobenzazepinones as gamma secretase
modulators (GSMs) are presented in this communication. Starting from our azepinone leads, …

Reversible janus associated kinase (JAK) inhibitors such as tofacitinib and decernotinib
block cytokine signaling and are efficacious in treating autoimmune diseases. However, …

Characterization of accurate compositions and total abundance of homologous drug-metabolizing
enzymes, such as UDP glucuronosyltransferases (UGTs), is important for predicting …