The reasons for hepatitis C treatment failure remain unknown but may be related to different
host responses to therapy. In this study, we compared hepatic gene expression in patients …

Background: Grapefruit juice (GFJ) enhances the systemic exposure of numerous CYP3A4
drug substrates, including felodipine, by inhibiting intestinal (but not hepatic) first-pass …

Uncontrolled observations implicate sulfate indrinking water at concentrations exceeding
500-700mg/liter as a cause of diarrhea, but controlled studieshave not been reported. We …

Objective Saquinavir, a widely prescribed human immunodeficiency virus 1 protease
inhibitor, has a low and variable oral bioavailability that has been attributed to extensive first‐pass …

Despite the increased emphasis on formal training in clinical and translational research and
the growth in the number and scope of training programs over the past decade, the impact …

Background We previously established furanocoumarins as mediators of the interaction
between grapefruit juice (GFJ) and the model CYP3A4 substrate felodipine in healthy volunteers …

We studied 276 fever episodes with an absolute neutrophil count (ANC) <500/m 3 to determine
patient characteristics predicting serious infection. Infections occurred in 38% of patients. …

Background Aphthous ulcers are common and painful. Current treatments are palliative and
focused on pain reduction. This article reports on the clinical trials of a novel, bioadhesive …

Despite several studies suggesting that CYP3A5 expression can influence the extent of
hepatic CYP3A-mediated inhibition, a systematic in vitro-in vivo evaluation of this potential …

The National Institute of Environmental Health Sciences is establishing a DNA repository
named the Environmental Polymorphisms Registry (EPR). The goal is to recruit 20,000 …