Dopamine is formed froml-tyrosine by tyrosine hydroxylase and aromaticl-amino acid
decarboxylase. In addition to this pathway, however, the formation of catecholamines, including …

We systematically characterized the levels and substrate specificity of P450s from humans
and rats to extrapolate drug metabolism data from experimental animals to humans. Human …

The purpose of the study was to elucidate human intestinal cytochrome P450 isoform(s)
involved in the metabolism of an antihistamine, ebastine, having two major pathways of …

In the sub-100-nm CMOS generation, a large local Vth variability degrades the 6T-SRAM cell
stability, so that we have to consider this local variability as well as the global variability to …

We immunochemically measured the contents of 9 different cytochrome P450 (CYP) isoenzymes
expressed in the liver and compared them between two groups: one group of 6 infant …

Apigenin, a plant-derived flavone, is a potent inhibitor of cell proliferation and angiogenesis,
but the mechanisms leading to the pathological anti-angiogenic effects of apigenin are still …

Hepatic microsomal cytochrome P450s, which are involved in the metabolism of drugs,
hormones, prostaglandins and fatty acids, change when animals develop diabetes. We studied …

Aims To determine the cytochrome P450 (CYP) isoforms involved in the oxidation of propofol
by human liver microsomes. Methods The rate constant calculated from the disappearance …

Nitric oxide (NO) modulates various metabolisms through interaction with thiol proteins and
hemoproteins. Although NO interacts reversibly with iron moieties of heme proteins, …

The existence of cytochrome P450 2D isoforms in the brain has been demonstrated, although
their physiological functions remain to be elucidated. In this study we demonstrated that …