Genome-wide association studies (GWAS) have laid the foundation for investigations into the
biology of complex traits, drug development and clinical guidelines. However, the majority …

Linear mixed models (LMMs) are widely used in genome-wide association studies (GWASs)
to account for population structure and relatedness, for both continuous and binary traits. …

Population structure inference with genetic data has been motivated by a variety of applications
in population genetics and genetic association studies. Several approaches have been …

Genealogical inference from genetic data is essential for a variety of applications in human
genetics. In genome-wide and sequencing association studies, for example, accurate …

US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental
exposures. Here, we characterized and controlled for this diversity in genome-wide …

The Genomic Data Storage (GDS) format provides efficient storage and retrieval of genotypes
measured by microarrays and sequencing. We developed GENESIS to perform various …

Food allergy (FA) affects 2%–10% of US children and is a growing clinical and public health
problem. Here we conduct the first genome-wide association study of well-defined FA, …

The Alzheimer’s Disease Sequencing Project (ADSP) undertook whole exome sequencing
in 5,740 late-onset Alzheimer disease (AD) cases and 5,096 cognitively normal controls …

Most genome-wide association and fine-mapping studies to date have been conducted in
individuals of European descent, and genetic studies of populations of Hispanic/Latino and …

Vancomycin-intermediate Staphylococcus aureus (VISA) is currently defined as having
minimal inhibitory concentration (MIC) of 4–8 µg/ml. VISA evolves through changes in multiple …