[BOOK][B] Biochemistry of antimicrobial action

TJ Franklin, GA Snow - 2013 - books.google.com
The rapid advances made in the study of the synthesis, structure and function of biological
macromolecules in the last fifteen years have enabled scientists concerned with antimicrobial …

The inhibition of nucleic acid synthesis by mycophenolic acid

TJ Franklin, JM Cook - Biochemical Journal, 1969 - portlandpress.com
1. Mycophenolic acid, an antibiotic of some antiquity that more recently has been found to
have marked activity against a range of tumours in mice and rats, strongly inhibits DNA …

[BOOK][B] Biochemistry and molecular biology of antimicrobial drug action

TJ Franklin, GA Snow - 2005 - books.google.com
Preface to the sixth edition x 1 THE DEVELOPMENT OF ANTIMICROBIAL AGENTS, PAST,
PRESENT AND FUTURE 1 1. 1 The social and economic importance of antimicrobial agents …

Therapeutic approaches to organ fibrosis

TJ Franklin - The international journal of biochemistry & cell biology, 1997 - Elsevier
Scarring of superficial tissues and chronic fibroses of major organs present major medical
problems ranging from disfigurement to progressive disability and death. Growing …

Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analog N-oxaloglycine and its derivatives

CJ Cunliffe, TJ Franklin, NJ Hales… - Journal of medicinal …, 1992 - ACS Publications
N-Oxaloglycine (3) is an-ketoglutarate (1) analogue that is a competitive inhibitor of prolyl 4-hydroxylase
(EC 1.14. 11.2). A study of the structure-activity relationships of some other …

Mycophenolic acid: an anti-cancer compound with unusual properties

SB Carter, TJ Franklin, DF Jones, BJ Leonard, SD Mills… - Nature, 1969 - nature.com
MYCOPHENOLIC acid (UK patent applications 43131/66 and 43132/66) emerged as a
potential anti-cancer compound during routine screening tests with mould filtrates for activity …

Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones

TJ Franklin, WP MORRIS, PN EDWARDS… - Biochemical …, 2001 - portlandpress.com
Examples of a novel series of phenanthrolinones are shown to be potent competitive inhibitors
of avian prolyl 4-hydroxylase, and of collagen hydroxylation, in embryonic chick tendon …

Glucuronidation associated with intrinsic resistance to mycophenolic acid in human colorectal carcinoma cells

TJ Franklin, V Jacobs, G Jones, P Plé, P Bruneau - Cancer research, 1996 - AACR
The in vivo efficacy of the antitumor, immunosuppressive antibiotic mycophenolic acid is
known to be limited by its rapid conversion to the biologically inactive 7-O-glucuronide, …

Resistance of Escherichia coli to tetracyclines. Changes in permeability to tetracyclines in Escherichia coli bearing transferable resistance factors

TJ Franklin - Biochemical Journal, 1967 - portlandpress.com
1. When strains of Escherichia coli, bearing transferable factors for resistance to the tetracyclines
(R-factors), and previously cultured in the absence of the tetracyclines, are grown for 15…

The formation of mercapturic acids. 2. The possible role of glutathionase

HG Bray, TJ Franklin, SP James - Biochemical Journal, 1959 - ncbi.nlm.nih.gov
Barnes, James & Wood (1959) reported results which could be explained by the hypothesis
that the first stage in the overall process of the formation of mercapturic acid from a precursor …