Why has model‐informed precision dosing not yet become common clinical reality? Lessons from the past and a roadmap for the future
…, P Vicini, L Aarons, TN Johnson… - Clinical …, 2017 - Wiley Online Library
Patient groups prone to polypharmacy and special subpopulations are susceptible to
suboptimal treatment. Refined dosing in special populations is imperative to improve therapeutic …
suboptimal treatment. Refined dosing in special populations is imperative to improve therapeutic …
[HTML][HTML] Physiologically-based pharmacokinetic models for children: Starting to reach maturation?
LFM Verscheijden, JB Koenderink, TN Johnson… - Pharmacology & …, 2020 - Elsevier
Developmental changes in children can affect the disposition and clinical effects of a drug,
indicating that scaling an adult dose simply down per linear weight can potentially lead to …
indicating that scaling an adult dose simply down per linear weight can potentially lead to …
The development of drug metabolising enzymes and their influence on the susceptibility to adverse drug reactions in children
TN Johnson - Toxicology, 2003 - Elsevier
Altered drug disposition in the developing child occurs as a result of both biochemical and
physiological changes. The clearance of many drugs is dependent on their biotransformation …
physiological changes. The clearance of many drugs is dependent on their biotransformation …
Search for Neutrinoless Double-Beta Decay in with EXO-200
…, S Herrin, M Hughes, A Johnson, TN Johnson… - Physical review …, 2012 - APS
We report on a search for neutrinoless double-beta decay of Xe 136 with EXO-200. No signal
is observed for an exposure of 32.5 kg yr, with a background of∼ 1.5× 10− 3 kg− 1 yr− 1 …
is observed for an exposure of 32.5 kg yr, with a background of∼ 1.5× 10− 3 kg− 1 yr− 1 …
Low-mass dark matter search with the DarkSide-50 experiment
…, A Ianni, A Ianni, V Ippolito, I James, TN Johnson… - Physical review …, 2018 - APS
We present the results of a search for dark matter weakly interacting massive particles (WIMPs)
in the mass range below 20 GeV/c 2 using a target of low-radioactivity argon with a …
in the mass range below 20 GeV/c 2 using a target of low-radioactivity argon with a …
Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children
TN Johnson, A Rostami-Hodjegan, GT Tucker - Clinical pharmacokinetics, 2006 - Springer
… The increase in intestinal CYP3A abundance with age as a fraction of the adult value was
modelled from the data of Johnson et al.,[39] assuming that the development of CYP3A in the …
modelled from the data of Johnson et al.,[39] assuming that the development of CYP3A in the …
Anatomical, physiological and metabolic changes with gestational age during normal pregnancy: a database for parameters required in physiologically based …
K Abduljalil, P Furness, TN Johnson… - Clinical …, 2012 - Springer
Background: Pregnancy is associated with considerable changes in the physiological,
anatomical and biochemical attributes in women. These may alter the exposure to xenobiotics …
anatomical and biochemical attributes in women. These may alter the exposure to xenobiotics …
Improved measurement of the half-life of Xe with the EXO-200 detector
…, M Hughes, XS Jiang, A Johnson, TN Johnson… - Physical Review C, 2014 - APS
We report on an improved measurement of the 2 ν β β half-life of 136 Xe performed by EXO-200.
The use of a large and homogeneous time-projection chamber allows for the precise …
The use of a large and homogeneous time-projection chamber allows for the precise …
Changes in liver volume from birth to adulthood: a meta-analysis
TN Johnson, GT Tucker, SM Tanner… - Liver …, 2005 - journals.lww.com
A diversity of equations is available for the estimation of liver volume (LV), derived from studies
in populations of ethnically homogeneous individuals and using a variety of methods of …
in populations of ethnically homogeneous individuals and using a variety of methods of …
DarkSide-50 532-day dark matter search with low-radioactivity argon
…, A Ianni, V Ippolito, I James, TN Johnson… - Physical Review D, 2018 - APS
The DarkSide-50 direct-detection dark matter experiment is a dual-phase argon time projection
chamber operating at Laboratori Nazionali del Gran Sasso. This paper reports on the …
chamber operating at Laboratori Nazionali del Gran Sasso. This paper reports on the …