PURPOSE: To assess polymerase chain reaction (PCR) analysis of intraocular fluid as a
test for infectious uveitis of the posterior segment in a representative patient population. …

Reaction phenotyping studies to identify specific enzymes involved in the metabolism of drug
candidates are increasingly important in drug discovery efforts. Experimental approaches …

A sensitive and quantitative method was developed for the estimation of reactive metabolite
formation in vitro. The method utilizes reduced glutathione (GSH) labeled with a …

The cytosolic fraction of human polymorphonuclear leukocytes precipitated with 60%
ammonium sulfate produced 5-lipoxygenase products from [14C]arachidonic acid and omega-6 …

The pH of ex vivo plasma, bile and urine was monitored at different times and temperatures
of storage, and following different sample processing methods such as ultrafiltration, …

Factor XIa (FXIa) is a blood coagulation enzyme that is involved in the amplification of
thrombin generation. Mounting evidence suggests that direct inhibition of FXIa can block …

A series of 2,4,5-tri-substituted imidazoles has proven to be highly potent in inhibiting mammalian
15-lipoxygenase (15-LO) with excellent selectivity over human isozymes 5- and P-12-…

A rotating arm apparatus capable of circumferential speeds up to 475 m/s (Mach 1·4) has
been used to make quantitative measurements of the velocity and angle dependence of rain …

Diazoxide (4) vasodilation. 1 The original excitement about the discovery of this class of
agents is somewhat dampened as no clear advantages of Katp openers over the existing …

A novel series of macrocyclic FXIa inhibitors was designed based on our lead acyclic phenyl
imidazole chemotype. Our initial macrocycles, which were double-digit nanomolar FXIa …