… [8] reported that a nonsynonymous single-nucleotide polymorphism (SNP) at 808G>T in
OCT2 was inversely correlated with the development of CDDP-induced nephrotoxicity. Thus, …

Pemetrexed, a multitargeted antifolate, is eliminated by tubular secretion via human organic
anion transporter 3 (hOAT3). Although proton pump inhibitors (PPIs) are frequently used in …

There is large interindividual variability in serum teicoplanin (TEIC) concentrations after
administration of a loading dose, and the factors that influence the pharmacokinetics of TEIC are …

Tacrolimus is important for immunosuppression in kidney transplantation. In this historical
cohort and in vitro study, we evaluated the changes in tacrolimus pharmacokinetics early after …

Our aim was to investigate whether a defect in vesicular monoamine transporter-2 (VMAT2)
activities would affect dopaminergic cell functions or not. We examined mesencephalon …

We herein report the first case of septic arthritis caused by rmpA-positive hypermucoviscous
communityacquired K. pneumoniae that followed urosepsis in a 65-year-old Japanese …

Background Both polypharmacy and frailty are critical issues faced by the elderly. The decrease
in gait speed is an index of frailty, and it is generally associated with falls and fractures, …

Background A dry powder inhaled formulation is used for the anti-influenza drug laninamivir
octanoate hydrate (laninamivir). Although two successive inhalations (puffs) are …

Background The optimal dose of mycophenolate mofetil (MMF) in renal transplant patients
has been recommended to be decided on the basis of area under the concentration-time …

Cases Case 1: A 20‐year‐old woman suffering a suspected overdose was transported to the
hospital. She presented bradycardia with wide QRS waves and QT prolongation, followed …