User profiles for T. Kasumov

Takhar Kasumov

NEOMED
Verified email at neomed.edu
Cited by 4516

Role of ceramides in nonalcoholic fatty liver disease

M Pagadala, T Kasumov, AJ McCullough… - Trends in endocrinology …, 2012 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is a chronic disease with a histological spectrum
ranging from steatosis alone, to nonalcoholic steatohepatitis (NASH). The latter is associated …

Mitochondrial redox regulation and myocardial ischemia-reperfusion injury

…, L Zhang, Z Jin, T Kasumov… - American Journal of …, 2022 - journals.physiology.org
Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of
disease and redox signaling in the cellular system. Under basal or pathological conditions, …

Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance

JM Haus, SR Kashyap, T Kasumov, R Zhang… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE—To quantitate plasma ceramide subspecies concentrations in obese subjects
with type 2 diabetes and relate these plasma levels to the severity of insulin resistance. …

[HTML][HTML] Ceramide as a mediator of non-alcoholic fatty liver disease and associated atherosclerosis

T Kasumov, L Li, M Li, K Gulshan, JP Kirwan, X Liu… - PloS one, 2015 - journals.plos.org
Cardiovascular disease (CVD) is a serious comorbidity in nonalcoholic fatty liver disease (NAFLD).
Since plasma ceramides are increased in NAFLD and sphingomyelin, a ceramide …

Hyperammonaemia‐induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress

…, CA Flask, C Hoppel, T Kasumov… - The Journal of …, 2016 - Wiley Online Library
Key points Hyperammonaemia occurs in hepatic, cardiac and pulmonary diseases with
increased muscle concentration of ammonia. We found that ammonia results in reduced skeletal …

Improved insulin sensitivity after exercise training is linked to reduced plasma C 14: 0 ceramide in obesity and type 2 diabetes

T Kasumov, TPJ Solomon, C Hwang, H Huang… - …, 2015 - Wiley Online Library
Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide
in obesity and type 2 diabetes - Kasumov - 2015 - Obesity - Wiley Online Library Skip to …

[PDF][PDF] Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor …

Y Li, M Zalzala, K Jadhav, Y Xu, T Kasumov, L Yin… - …, 2016 - Wiley Online Library
… Statistical significance was analyzed using unpaired Student t test or analysis of variance
(GraphPad Prism; GraphPad Software Inc., La Jolla, CA). All values are expressed as mean 6 …

Gastric bypass surgery reduces plasma ceramide subspecies and improves insulin sensitivity in severely obese patients

H Huang, T Kasumov, P Gatmaitan, HM Heneghan… - …, 2011 - Wiley Online Library
Bariatric surgery is associated with near immediate remission of type 2 diabetes and
hyperlipidemia. The mechanisms underlying restoration of normal glucose tolerance …

[HTML][HTML] Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR

…, Y Li, J Xu, Y Zhu, L Adorini, YK Lee, T Kasumov… - Molecular …, 2018 - Elsevier
Objectives Activation of the bile acid (BA) receptors farnesoid X receptor (FXR) or G protein-coupled
bile acid receptor (GPBAR1; TGR5) improves metabolic homeostasis. In this study, …

Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry

T Kasumov, H Huang, YM Chung, R Zhang… - Analytical …, 2010 - Elsevier
We present an optimized and validated liquid chromatography electrospray ionization
tandem mass spectrometry (LC–ESI–MS/MS) method for the simultaneous measurement of …