In vitro permeability experiments are used widely in drug discovery and other areas of
pharmaceutical research. Much effort has been expended in developing novel epithelial models …

The transient receptor potential ankyrin 1 ( TRPA 1) ion channel on peripheral terminals of
nociceptive primary afferent nerve fibres contributes to the transduction of noxious stimuli to …

Caco-2 cells, widely used to study carrier mediated uptake and efflux mechanisms, are known
to have different properties when cultured under different conditions. In this study, Caco-2 …

Loss of drug content during cell culture transport experiment can lead to misinterpretations
in permeability analysis. This study analyses drug adsorption to various plastic containers …

… Mean ODM-207 AUC (0-t) increased between day 1 and day 15 of dosing by 3.4-fold (n =
28, 95% CI 2.9, 3.8). Cohort mean total plasma concentrations on day 1 and day 15 (steady …

… The t max and t ½ for both midazolam and non-conjugated dabigatran were comparable
in the presence and absence of darolutamide. Hence, darolutamide showed only weak CYP …

One major prerequisite for an orally administered drug is the ability to cross the intestinal
epithelia from intestinal lumen into the blood circulation. Therefore, the absorption potential of …

… 4 shows the overall FE in AUC 0–t,last predictions for all single dose, fasted state, iv and po
… AUC 0–t,last values were slightly overpredicted, with a median FE for AUC 0–t,last of 1.56 …

… Sections 3.1–3.3 detail the influence of compound properties of interest on the predictive
performance of different PK parameters including AUC 0-t,last , F oral , F rel , C max , CL or CL/…

Oral drug absorption is a complex process depending on many factors, including the
physicochemical properties of the drug, formulation characteristics and their interplay with …