User profiles for T. Mead
Thomas MeadPhD Student, The Francis Crick Institute Verified email at crick.ac.uk Cited by 274 |
ADAMTS proteins in human disorders
TJ Mead, SS Apte - Matrix Biology, 2018 - Elsevier
ADAMTS proteins are a superfamily of 26 secreted molecules comprising two related, but
distinct families. ADAMTS proteases are zinc metalloendopeptidases, most of whose …
distinct families. ADAMTS proteases are zinc metalloendopeptidases, most of whose …
Closed fractures of the tibial shaft. A meta-analysis of three methods of treatment
B Littenberg, LP Weinstein, M McCarren, T Mead… - JBJS, 1998 - journals.lww.com
We reviewed the literature to determine the clinical outcomes of the treatment of closed
fractures of the tibial shaft with immobilization in a cast, open reduction with internal fixation, or …
fractures of the tibial shaft with immobilization in a cast, open reduction with internal fixation, or …
[HTML][HTML] OpenABM-Covid19—An agent-based model for non-pharmaceutical interventions against COVID-19 including contact tracing
… Combining all effects, we model the hazard rate per interaction at which the virus is transmitted
by where t is the time since the source was infected; d indicates the disease severity of …
by where t is the time since the source was infected; d indicates the disease severity of …
A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP
MA Leissring, MP Murphy, TR Mead… - Proceedings of the …, 2002 - National Acad Sciences
… Mouse embryonic fibroblasts were immortalized by transfection with the large-T antigen
of SV40. N2a cells were maintained in a 1:1 mixture of DMEM/10% FBS and Optimem I …
of SV40. N2a cells were maintained in a 1:1 mixture of DMEM/10% FBS and Optimem I …
Providing recording of clinical consultation to patients–a highly valued but underutilized intervention: a scoping review
Objective The benefits of providing patients with recorded clinical consultations have been
mostly investigated in oncology settings, generally demonstrating positive outcomes. There …
mostly investigated in oncology settings, generally demonstrating positive outcomes. There …
Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease
…, AF Haughan, C O'Connell, T Mead… - Journal of medicinal …, 2013 - ACS Publications
Inhibition of class IIa histone deacetylase (HDAC) enzymes have been suggested as a
therapeutic strategy for a number of diseases, including Huntington’s disease. Catalytic-site small …
therapeutic strategy for a number of diseases, including Huntington’s disease. Catalytic-site small …
Synthesis of glutathione
CR Harington, TH Mead - Biochemical Journal, 1935 - ncbi.nlm.nih.gov
… confirmed by Kendall, Mason and McKenzie [1930, 2] for the crystalline peptide and these
workers also showed [1930, 1] that oxidation of glutathione with hypobromite or chloramine T …
workers also showed [1930, 1] that oxidation of glutathione with hypobromite or chloramine T …
Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development
TJ Mead, KE Yutzey - … of the National Academy of Sciences, 2009 - National Acad Sciences
The role of Notch signaling in cartilage differentiation and maturation in vivo was examined.
Conditional Notch pathway gain and loss of function was achieved using a Cre/loxP …
Conditional Notch pathway gain and loss of function was achieved using a Cre/loxP …
[HTML][HTML] Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection
FS Cikach, CD Koch, TJ Mead, J Galatioto, BB Willard… - JCI insight, 2018 - ncbi.nlm.nih.gov
Proteoglycan accumulation is a hallmark of medial degeneration in thoracic aortic
aneurysm and dissection (TAAD). Here, we defined the aortic proteoglycanome using mass …
aneurysm and dissection (TAAD). Here, we defined the aortic proteoglycanome using mass …
Proliferation assays (BrdU and EdU) on skeletal tissue sections
TJ Mead, V Lefebvre - Skeletal Development and Repair: Methods and …, 2014 - Springer
Assessing cell proliferation in situ is an important phenotyping component of skeletal
tissues from development to adult stages and disease. Various methods exist including …
tissues from development to adult stages and disease. Various methods exist including …