Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
TH Stracker, T Usui, JHJ Petrini - DNA repair, 2009 - Elsevier
The cellular DNA damage response (DDR) is activated by many types of DNA lesions. Upon
recognition of DNA damage by sensor proteins, an intricate signal transduction network is …
recognition of DNA damage by sensor proteins, an intricate signal transduction network is …
Pharmaceutical prospects of phytoestrogens
T Usui - Endocrine journal, 2006 - jstage.jst.go.jp
Interest in the physiologic and pharmacologic role of bioactive compounds present in plants
has increased dramatically over the last decade. Of particular interest in relation to human …
has increased dramatically over the last decade. Of particular interest in relation to human …
[HTML][HTML] Pivotal roles of GM-CSF in autoimmunity and inflammation
A Shiomi, T Usui - Mediators of inflammation, 2015 - hindawi.com
… (not IL-17) is critical for the pathogenicity of CD4 + T cells. Therefore, the mechanism of
GM-CSF-producing CD4 + T cell differentiation and the role of GM-CSF in the development of …
GM-CSF-producing CD4 + T cell differentiation and the role of GM-CSF in the development of …
Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans
…, S Toyooka, G Shirakami, T Usui… - The Journal of …, 2001 - academic.oup.com
… Comparisons between groups were performed with unpaired t test. Changes in the plasma
ghrelin-LI level after fasting and feeding were compared using paired t test. Simple linear …
ghrelin-LI level after fasting and feeding were compared using paired t test. Simple linear …
Ghrelin strongly stimulates growth hormone release in humans
… It should be emphasized, however, that the lowest dose of ghrelin used in the present study
(0.2 ug/kg) could still lead to massive GH release (43.3 t 6.0 ng/mL) with minimum effects on …
(0.2 ug/kg) could still lead to massive GH release (43.3 t 6.0 ng/mL) with minimum effects on …
Thyroid hormone action is disrupted by bisphenol A as an antagonist
… The inhibitory effects were observed in the presence of physiological concentrations of T 3 .
… by T 3 . To elucidate possible mechanisms of the antagonistic action of BPA, the effects on T …
… by T 3 . To elucidate possible mechanisms of the antagonistic action of BPA, the effects on T …
[HTML][HTML] Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus
…, H Nishimura, K Mitamura, N Sugaya, T Usui, T Murata… - Nature, 2004 - nature.com
The ‘Spanish’ influenza pandemic of 1918–19 was the most devastating outbreak of infectious
disease in recorded history. At least 20 million people 1 died from their illness, which was …
disease in recorded history. At least 20 million people 1 died from their illness, which was …
[HTML][HTML] Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled
T Usui, Y Shima, Y Shimada, S Hirano, RW Burgess… - Cell, 1999 - cell.com
… The fmi null mutations were embryonic lethal, and the mutant embryos showed local
disconnection of longitudinal axon fascicles in the central nervous system (T. Usui and T. Uemura, …
disconnection of longitudinal axon fascicles in the central nervous system (T. Usui and T. Uemura, …
Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors
…, T Horimoto, K Shinya, T Sawada, M Kiso, T Usui… - Nature, 2006 - nature.com
H5N1 influenza A viruses have spread to numerous countries in Asia, Europe and Africa,
infecting not only large numbers of poultry, but also an increasing number of humans, often …
infecting not only large numbers of poultry, but also an increasing number of humans, often …
[HTML][HTML] Preliminary analysis of the Hayabusa2 samples returned from C-type asteroid Ryugu
…, S Furuya, M Uesugi, Y Karouji, T Usui, T Hayashi… - Nature …, 2022 - nature.com
… where a and b are the major and minor Fetet diameters, respectively, measured from its
optical microscopic image and t is thickness, measured by focusing on the top and bottom of the …
optical microscopic image and t is thickness, measured by focusing on the top and bottom of the …