Activation of pharmacologic agents to radical intermediates: implications for the role of free radicals in drug action and toxicity

MA Trush, EG Mimnaugh, TE Gram - Biochemical pharmacology, 1982 - Elsevier
The biological effects of exogenous chemicals, including drugs, are initiated through
physiochemical interactions between the chemical and specific tissue macromolecules such as …

Chemically reactive intermediates and pulmonary xenobiotic toxicity

TE Gram - Pharmacological reviews, 1997 - ASPET
The biochemical literature abounds with reviews of drug oxidation and conjugation by and
toxic effects in liver (Gillette, 1974a, b). Although it was once believed that drug-induced …

[PDF][PDF] Comparison of in vitro drug metabolism by lung, liver, and kidney of several common laboratory species

…, EG MIMNAUGH, RL REAGAN, TE GRAM - Drug Metabolism and …, 1975 - Citeseer
Comparative studies of in vitro drug metabolism by hepatic and extrahepatic tissues have
been complicated by the use of a single experimental tissue. few animal species. and variable …

Distribution and Disposition of Platinum following Intravenous Administration of cis-Diamminedichloroplatinum(II) (NSC 119875) to Dogs

CL Litterst, TE Gram, RL Dedrick, AF Leroy… - Cancer Research, 1976 - AACR
cis-Diamminedichloroplatinum(II) is an antineoplastic drug that is undergoing a renewed
clinical interest as a drug for use in combination regimens. In order to increase the …

The metabolism of xenobiotics by certain extrahepatic organs and its relation to toxicity

TE Gram, LK Okine, RA Gram - Annual review of pharmacology …, 1986 - annualreviews.org
Considerable interest has developed in recent years in the bioactivation of xenobiotics in
extrahepatic organs and in the accompanying toxic effects in these organs. However, the …

In vitro stimulation by paraquat of reactive oxygen-mediated lipid peroxidation in rat lung microsomes

…, EG Mimnaugh, E Ginsburg, TE Gram - Toxicology and applied …, 1981 - Elsevier
Paraquat significantly stimulated lipid peroxidation in rat lung microsomes without the
addition of exogenous iron. The ability of paraquat to stimulate this lipid peroxidation was …

Enhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycin

…, MA Trush, M Bhatnagar, TE Gram - Biochemical …, 1985 - Elsevier
Mitochondrial degeneration is a consistently prominent morphological alteration associated
with adriamycin toxicity which may be the consequence of adriamycin-enhanced …

Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates

PL GIGON, TE GRAM, JR GILLETTE - Molecular pharmacology, 1969 - ASPET
Optimum conditions are described for the assay of cytochrome P-450 reduction by NADPH
in rat liver microsomes. The addition in vitro of chemical compounds which produce type I …

Stimulation by adriamycin of rat heart and liver microsomal NADPH-dependent lipid peroxidation

EG Mimnaugh, MA Trush, TE Gram - Biochemical pharmacology, 1981 - Elsevier
Rat liver and heart microsomes catalyze the transfer of single electrons from NADPH to
adriamycin forming semiquinone radicals which, in turn, activate molecular oxygen. This process …

[HTML][HTML] Improved Therapeutic Index of Bleomycin When Administered by Continuous Infusion in Mice ¹

…, JM Collins, EG Mimnaugh, TE Gram - Cancer Treatment …, 1978 - books.google.com
The effects of three different dosage schedules on both therapeutic effect and pulmonary
toxicity of bleomycin were studied in mice. Therapy was assessed by both survival and …